Document Detail

Influence of boric acid on electrospray ionization efficiency.
MedLine Citation:
PMID:  22792616     Owner:  NLM     Status:  In-Process    
Liquid chromatography electrospray ionization mass-spectrometry (LC-ESI-MS) was used to analyze 9-fluorenylmethylmethoxycarbonyl chloride (Fmoc-Cl) and diethyl ethoxymethylenemalonate (Deemm) derivatives of three amino acids and five other compounds. Influence of boric acid on their ionization was investigated and dramatic impact on the signal was observed. The strongest signal suppression (6% of signal remains) was observed for the Deemm derivative of beta-Alanine (with ammonium acetate in eluent). With only formic acid as the eluent pH modifier, signal enhancement was observed, being largest for Fmoc-Cl derivative of Phenylalanine, 267%. Investigation of the influence of boric acid shows that it is a possible signal enhancer for LC-ESI-MS analysis.
Riin Rebane; Koit Herodes
Related Documents :
22204646 - Contribution of rpfb to cell-cell signal synthesis, virulence, and vector transmission ...
12027746 - Multibranched polyunsaturated and very-long-chain fatty acids of freshwater israeli spo...
21815426 - Valine and phenylalanine as precursors in the biosynthesis of alkamides in acmella radi...
23567836 - Efficiency of yeast in enhancement of the oxidative defense system in salt-stressed fla...
2069816 - Two genes encode distinct glutamate decarboxylases.
23086596 - Structure-activity differences of chlorogenic acid and its isomers on sensitization via...
Publication Detail:
Type:  Letter    
Journal Detail:
Title:  European journal of mass spectrometry (Chichester, England)     Volume:  18     ISSN:  1469-0667     ISO Abbreviation:  Eur J Mass Spectrom (Chichester, Eng)     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101124748     Medline TA:  Eur J Mass Spectrom (Chichester, Eng)     Country:  England    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of two species of Notopterygium by high-performance liquid chromatography-photodiode arra...
Next Document:  Breaking the surface: Arm yourself with knowledge about penetrating trauma.