| Influence of body weight on the severity of dyspnea in chronic obstructive pulmonary disease. | |
MedLine Citation:
|
PMID: 10712338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A substantial number of patients with COPD are underweight (UW); they comprise the clinical subtype of "dyspneic" or emphysematous. To determine whether these patients are more dyspneic than normal weight (NW) patients with COPD, we quantitated the severity of dyspnea, using a modified Medical Research Council (MRC) dyspnea scale, in 33 UW and 57 NW patients and compared their pulmonary function tests (PFTs), arterial blood gases (ABGs), and respiratory muscle strength as estimated by maximum static inspiratory (PI(max)) and expiratory (PE(max)) mouth pressures (all as means +/- SEM). Body mass index was 18.7 +/- 1.2 and 24.5 +/- 1.8 kg/m(2) in UW and NW patients, respectively (p < 0.0001). The MRC dyspnea scale was 3. 1 +/- 0.9 in UW and 2.5 +/- 1.2 in NW groups (p = 0.035). All PFT and ABG parameters were similar in the two groups except for DCO (36 +/- 11% in UW and 57 +/- 17% in NW, p < 0.001) and PI(max) (55 +/- 18 mm Hg in UW and 66 +/- 19 mm Hg in NW, p = 0.020). In a stepwise multiple regression model, %DCO and %MVV combined were the best predictors of dyspnea severity (R(2) = 0.30, p = 0.001). We conclude that UW patients with COPD are more dyspneic than NW patients. Although the origin of dyspnea in COPD is multifactorial, changes in DCO and respiratory muscle strength may contribute to its intensity. |
Authors:
|
H Sahebjami; E Sathianpitayakul |
Related Documents
:
|
3019988 - Effects of alveolar pressure on lung angiotensin-converting enzyme function in vivo. 7086608 - Changes in pulmonary function during the diuretic phase of respiratory distress syndrome. 8741268 - Effect of positive end-expiratory pressure on extravascular lung water and cardiopulmon... 3932318 - Vascular and airway effects of endogenous cyclooxygenase products during lung inflation. 2299088 - Use of a perforated balloon catheter to deliver concentrated heparin into the wall of t... 22668978 - The effect of selective laser trabeculoplasty on aqueous humor dynamics in patients wit... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of respiratory and critical care medicine Volume: 161 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2000 Mar |
Date Detail:
|
Created Date: 2000-04-25 Completed Date: 2000-04-25 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 886-90 Citation Subset: AIM; IM |
Affiliation:
|
Pulmonary Section, Department of Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Body Mass Index Body Weight / physiology* Dyspnea / diagnosis, physiopathology* Humans Lung Diseases, Obstructive / diagnosis, physiopathology* Male Middle Aged Pulmonary Gas Exchange / physiology Reference Values Respiratory Function Tests Respiratory Muscles / physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Respiratory muscle recruitment and exercise performance in eucapnic and hypercapnic severe chronic o...
Next Document: Modulation of release of reactive oxygen species by the contracting diaphragm.