Document Detail

Influence of body weight on the severity of dyspnea in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  10712338     Owner:  NLM     Status:  MEDLINE    
A substantial number of patients with COPD are underweight (UW); they comprise the clinical subtype of "dyspneic" or emphysematous. To determine whether these patients are more dyspneic than normal weight (NW) patients with COPD, we quantitated the severity of dyspnea, using a modified Medical Research Council (MRC) dyspnea scale, in 33 UW and 57 NW patients and compared their pulmonary function tests (PFTs), arterial blood gases (ABGs), and respiratory muscle strength as estimated by maximum static inspiratory (PI(max)) and expiratory (PE(max)) mouth pressures (all as means +/- SEM). Body mass index was 18.7 +/- 1.2 and 24.5 +/- 1.8 kg/m(2) in UW and NW patients, respectively (p < 0.0001). The MRC dyspnea scale was 3. 1 +/- 0.9 in UW and 2.5 +/- 1.2 in NW groups (p = 0.035). All PFT and ABG parameters were similar in the two groups except for DCO (36 +/- 11% in UW and 57 +/- 17% in NW, p < 0.001) and PI(max) (55 +/- 18 mm Hg in UW and 66 +/- 19 mm Hg in NW, p = 0.020). In a stepwise multiple regression model, %DCO and %MVV combined were the best predictors of dyspnea severity (R(2) = 0.30, p = 0.001). We conclude that UW patients with COPD are more dyspneic than NW patients. Although the origin of dyspnea in COPD is multifactorial, changes in DCO and respiratory muscle strength may contribute to its intensity.
H Sahebjami; E Sathianpitayakul
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  161     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-25     Completed Date:  2000-04-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  886-90     Citation Subset:  AIM; IM    
Pulmonary Section, Department of Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA.
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MeSH Terms
Body Mass Index
Body Weight / physiology*
Dyspnea / diagnosis,  physiopathology*
Lung Diseases, Obstructive / diagnosis,  physiopathology*
Middle Aged
Pulmonary Gas Exchange / physiology
Reference Values
Respiratory Function Tests
Respiratory Muscles / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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