| The influence of body mass index and renin-angiotensin-aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in Caucasian men. | |
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MedLine Citation:
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PMID: 21402748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Previous studies have suggested that circulating adiponectin concentrations are associated positively with vitamin D and negatively with body mass index (BMI) but have not accounted for the influence of the renin-angiotensin-aldosterone system (RAAS) in this relationship. This is particularly relevant because increased RAAS activity is associated with obesity and is known to lower adiponectin levels. We evaluated the association between adiponectin and 25-hydroxyvitamin D (25(OH)D) after controlling RAAS activity with dietary sodium equilibration and also evaluated whether this relationship was influenced by BMI. DESIGN: Cross-sectional study of 115 hypertensive Caucasian men from the Hypertensive Pathotype Consortium. METHODS: To manipulate RAAS activity, all subjects underwent 1 week of high dietary sodium (HS) diet to suppress RAAS and 1 week of low dietary sodium (LS) diet to stimulate RAAS. Linear regression was used to evaluate the association between adiponectin and 25(OH)D, and the effect of BMI on this relationship, in each dietary condition. RESULTS: Adiponectin was higher on HS, where circulating RAAS activity was low, when compared with LS (HS=2.9 versus LS=2.4 μg/ml, P<0.0001). 25(OH)D levels were positively associated with adiponectin, and BMI was a statistically significant effect modifier of the relationship between 25(OH)D and adiponectin on both diets (P interaction <0.01 between BMI and 25(OH)D). CONCLUSIONS: Higher 25(OH)D concentrations were independently associated with higher adiponectin levels, particularly when BMI was high. Dietary sodium balance and circulating RAAS activity did not appear to affect this relationship. Future studies should explore whether vitamin D supplementation increases adiponectin levels in obesity. |
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Authors:
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Anand Vaidya; John P Forman; Patricia C Underwood; Paul N Hopkins; Gordon H Williams; Luminita H Pojoga; Jonathan S Williams |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-03-14 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 164 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-30 Completed Date: 2011-07-29 Revised Date: 2012-02-08 |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 995-1002 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, 221 Longwood Avenue, RFB 386, Boston, Massachusetts 02115, USA. avaidya1@partners.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Adipose Tissue / physiology Adult Aged Body Mass Index* Cross-Sectional Studies European Continental Ancestry Group Homeostasis / physiology Humans Hydroxycholecalciferols / blood* Hypertension / blood Insulin Resistance / physiology Linear Models Male Middle Aged Renin-Angiotensin System / physiology* Sodium, Dietary / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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F31 NR011108-01/NR/NINR NIH HHS; F31 NR011108-03/NR/NINR NIH HHS; F32 HL104776-01/HL/NHLBI NIH HHS; F32 HL104776-01/HL/NHLBI NIH HHS; K08 HL079929/HL/NHLBI NIH HHS; K08 HL079929-04/HL/NHLBI NIH HHS; K23 HL08236-03/HL/NHLBI NIH HHS; K23 HL084236-04/HL/NHLBI NIH HHS; KL2 RR025757/RR/NCRR NIH HHS; M01-RR02635/RR/NCRR NIH HHS; P50HL055000/HL/NHLBI NIH HHS; U54LM008748/LM/NLM NIH HHS; UL1 RR025758/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Hydroxycholecalciferols; 0/Sodium, Dietary |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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