| Influence of blood viscosity to cerebral blood flow in older humans compared to young subjects. | |
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MedLine Citation:
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PMID: 21724459 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Since blood viscosity (BV) is one of the most important factors determining blood flow, this study aimed to investigate the possible correlation between increased blood viscosity and reduction of regional cerebral blood flow (rCBF) in healthy ageing. METHODS: Male subjects were distributed in two groups: "young", aged 20-30 (27 volunteers), or "elderly", aged 60-70 (50 volunteers). Whole blood viscosity was obtained with a Wells-Brookfield Cone/Plate Viscometer. Cerebral blood flow was analysed by means of single photon emission computed tomography (SPECT). RESULTS: The mean BV values were 3.28±0.43mPa in the group of young volunteers and 4.33±0.73mPa in the group of elderly volunteers (t=-6.9, p<0.0001). The elderly had a lower blood flow than the young in the following regions: bilateral parietal; temporal-parietal and temporal of the left hemisphere. Pearson's correlation between BV and rCBF showed a good inverse correlation when the BV was above 3.95±0.83mPa. CONCLUSIONS: Our results point to a close relationship between the two parameters analysed, BV and rCBF. The impairment in rCBF observed in the elderly volunteers might be due to an increase in BV, among other factors. SIGNIFICANCE: These findings suggest interesting possibilities for the treatment/prevention of brain ageing. |
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Authors:
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Ruth F Santos-Galduróz; Orlando F A Bueno; Lilian I Yamaga; Fernanda Armani; José Carlos F Galduróz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-1 |
Journal Detail:
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Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: - ISSN: 1872-8952 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883319 Medline TA: Clin Neurophysiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Biosciences, Universidade Estadual Paulista, Rio Claro, SP, Brazil; Center for Mathematics, Computing and Cognition, Universidade Federal do ABC, Santo André, SP, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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