Document Detail

Influence of blood storage after in vitro exposure on the yield of micronuclei observed in human lymphocytes.
MedLine Citation:
PMID:  8488462     Owner:  NLM     Status:  MEDLINE    
In a cooperative study, four laboratories evaluated the micronucleus test in irradiated and non-irradiated lymphocytes with respect to time of storage, the difference between X-ray and gamma exposure and inter-observer variance. The results were compared with parallel studies on dicentric aberrations. No significant differences between laboratories, with respect to storage time or between gamma and X-irradiation were observed for micronuclei and dicentrics using analysis of variance. However, micronuclei are not suitable for an assessment of exposure inhomogeneity because of a significant overdispersion already in controls and homogeneously irradiated samples.
I Lopez; A Hilali; L Verschaeve; C Laurent; C Bugueno; E D Léonard; A Maes; P Jadot; G Goens; S Sanhueza
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]     Volume:  169     ISSN:  0179-7158     ISO Abbreviation:  Strahlenther Onkol     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-06-07     Completed Date:  1993-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8603469     Medline TA:  Strahlenther Onkol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  258-62     Citation Subset:  IM    
Laboratorio Dosimetria Biologica, CEN La Reina, Santiago, Chile.
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MeSH Terms
Blood Preservation* / statistics & numerical data
Dose-Response Relationship, Radiation
Lymphocytes / radiation effects*,  ultrastructure
Micronuclei, Chromosome-Defective / radiation effects*
Micronucleus Tests / statistics & numerical data
Observer Variation
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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