| Influence of biosynthetic human growth hormone on the biomechanical strength development in skin incisional wounds of diabetic rats. | |
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MedLine Citation:
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PMID: 8500507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of biosynthetic human growth hormone (b-hGH) on the mechanical strength development of skin incisional wounds in diabetic rats has been investigated after 4, 7 and 21 days of healing. Diabetes caused decreased mechanical strength of the wounds. After 21 days of healing, the diabetic animals treated with b-hGH from 7 days before wound infliction had an increased maximum load (14%) compared with the untreated diabetic animals. After 4 and 7 days of healing, no differences in the biomechanical strength of diabetic wounds with and without b-hGH treatment were found. The diabetic animals receiving b-hGH showed a significant increase in body weight compared with the untreated diabetic animals. In the diabetic animals, the blood glucose concentration was increased by treatment with b-hGH. In conclusion, treatment with b-hGH from 7 days before operation can counteract the reduced mechanical strength of skin wounds in diabetic rats on day 21. |
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Authors:
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M Seyer-Hansen; T T Andreassen; P H Jørgensen; H Oxlund |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 25 ISSN: 0014-312X ISO Abbreviation: Eur Surg Res Publication Date: 1993 May-Jun |
Date Detail:
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Created Date: 1993-06-29 Completed Date: 1993-06-29 Revised Date: 2006-11-30 |
Medline Journal Info:
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Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 162-8 Citation Subset: IM; S |
Affiliation:
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Department of Connective Tissue Biology, University of Aarhus, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomechanics Blood Glucose / metabolism Body Weight / drug effects Diabetes Mellitus, Experimental / complications, physiopathology* Female Growth Hormone / administration & dosage, pharmacology* Rats Rats, Wistar Skin / injuries*, physiopathology Wound Healing / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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