Document Detail

Influence of bioresorbable, unsintered hydroxyapatite/poly-L-lactide composite films on spinal cord, nerve roots, and epidural space.
MedLine Citation:
PMID:  11835165     Owner:  NLM     Status:  MEDLINE    
The effect of forged unsintered hydroxyapatite/poly-L-lactide (u-HA/PLLA) composite films on spinal cord and nerve roots and its degradation behavior and osteoconductivity in epidural space were compared with those of calcined HA (c-HA)/PLLA and unfilled PLLA films. Partial laminectomy was performed on 20 rabbits, and u-HA/PLLA and PLLA films were implanted in the intervertebral space. Total laminectomy was performed on 30 rabbits to implant u-HA/PLLA, c-HA/PLLA, and PLLA films in both epidural and subcutaneous spaces. For up to 50 weeks, there were no histological changes in the spinal cord or nerve root, and no inflammatory cell infiltration into the epidural space around the films. The rate of decrease in viscosity average molecular weight of both composite films was initially higher than that of PLLA but eventually became lower, although there was no difference in the degradation behavior of the three films in either the epidural or subcutaneous spaces after 50 weeks. Scanning electron microscopic and energy-dispersive X-ray analysis indicated calcium phosphate deposits on the surface of composite films with new bone formation from 4 weeks. The u-HA/PLLA composite film therefore has good biocompatibility, osteoconductivity, and fast primary degradation rate, which may prove compatible with application to spinal surgery.
Masanori Matsumoto; Etsuo Chosa; Kazuki Nabeshima; Yasuo Shikinami; Naoya Tajima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical materials research     Volume:  60     ISSN:  0021-9304     ISO Abbreviation:  J. Biomed. Mater. Res.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-02-08     Completed Date:  2002-05-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0112726     Medline TA:  J Biomed Mater Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-9     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Inc. J Biomed Mater Res 60: 101-109, 2002
Department of Orthopedics, Miyazaki Medical College, 5200, Kiwara, Kiyotake-cho, Miyazaki 889-1692, Japan.
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MeSH Terms
Biocompatible Materials / chemistry,  pharmacology*
Bone and Bones / physiology
Durapatite / chemistry,  pharmacology*
Electric Conductivity
Epidural Space / cytology*,  drug effects*
Materials Testing
Microscopy, Electron, Scanning
Molecular Weight
Polyesters / pharmacology*
Spinal Cord / cytology,  drug effects*,  growth & development
Spinal Nerve Roots / cytology,  drug effects*,  growth & development
Tissue Fixation
Reg. No./Substance:
0/Biocompatible Materials; 0/Polyesters; 1306-06-5/Durapatite; 26969-66-4/poly(lactide)

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