| Influence of bile flow interruption on acute experimental pancreatitis. | |
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MedLine Citation:
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PMID: 6206023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of bile flow interruption on the pathogenesis of acute pancreatitis has been evaluated in the rat. The pancreatitis was induced by Pfeffer's technique and the severity of the disease was assessed by a macroscopic examination of the pancreatic damage and the calculation of amylase-to-creatinine clearance ratio (ACCR) as well. The results showed that the bile reflux into the pancreas made the pancreatic lesions caused by stasis in the gland associated with hyperstimulation of exocrine secretion more severe. On the other hand the bile reflux had no influence when the pancreatitis was due to flowing back of duodenal contents into the pancreas (closed duodenal loop). It was concluded that the bile effect is probably consistent with a pressure mechanism. In addition the reliability of ACCR in the diagnosis of acute pancreatitis was confirmed, and the test was effective in detecting even milder pancreatic damages. |
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Authors:
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L Sarli; M Gafà; M Lupi; A Peracchia |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Italian journal of surgical sciences / sponsored by Società italiana di chirurgia Volume: 14 ISSN: 0392-3525 ISO Abbreviation: Ital J Surg Sci Publication Date: 1984 |
Date Detail:
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Created Date: 1984-09-28 Completed Date: 1984-09-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8213451 Medline TA: Ital J Surg Sci Country: ITALY |
Other Details:
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Languages: eng Pagination: 119-23 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Amylases / metabolism Animals Bile / secretion Bile Reflux / complications*, physiopathology Biliary Tract Diseases / complications* Cholestasis / complications Creatinine / metabolism Evaluation Studies as Topic Male Pancreatitis / etiology*, metabolism, physiopathology Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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