| Influence of attenuation correction by integrated low-dose CT on somatostatin receptor SPECT. | |
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MedLine Citation:
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PMID: 17728608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Somatostatin receptor scintigraphy (SRS) is well-established in neuroendocrine tumour (NET) imaging. This study evaluated the impact of attenuation correction (AC) on SRS SPECT data in patients examined by SPECT-CT. METHODS: Planar scintigraphy and SPECT-CT of 17 patients (10 men, seven women; age, 40-74 years; mean, 62 years) suffering from NET were included. For the visual assessment of AC, the intensity and contrast of foci classified as pathological were rated in both the non-attenuation corrected (NAC) and the attenuation corrected (AC) SPECT images using a 5-point score. The change in signal intensity after AC was semiquantified two-fold for each focus in both SPECT(AC) and SPECT(NAC): firstly by using tumour-to-background (TB) ratios (defined as T(max)/B(mean)) for the determination of a TB(AC)/TB(NAC) ratio. Secondly, by a T(max,AC)/T(max,NAC) ratio. Both ratios were correlated to the focus depth. RESULTS: A total of 46 pathological foci were found. Focus contrast and intensity significantly increased in 14/46 foci (30%) after AC (mean, 3.7-4.0) in the visual analysis (P<0.001). While TB ratios increased only in 24/46 foci after AC and no correlation between the T(BAC)/T(BNAC) ratio and focus depth (r=0.027; P=0.856) was found, T(max) was higher after AC in all foci and the T(max,AC)/T(max,NAC) ratio showed the expected correlation to focus depth (r=0.650; P<0.01), indicating the superiority of the Tmax approach for the demonstration of the effects of attenuation correction on focal uptake. CONCLUSION: Attenuation correction of SRS SPECT data by SPECT-CT results in visually more clearly contrasted foci. Moreover, as focus intensity increases, especially in the more centrally localised foci, CT-based AC has a potential to further improve the sensitivity of SRS SPECT. |
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Authors:
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Juri Ruf; Ingo Steffen; Sebastian Mehl; Christian Rosner; Timm Denecke; Ulrich-Frank Pape; Michail Plotkin; Holger Amthauer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nuclear medicine communications Volume: 28 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-08-30 Completed Date: 2007-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: England |
Other Details:
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Languages: eng Pagination: 782-8 Citation Subset: IM |
Affiliation:
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Klinik für Strahlenheilkunde, Charité, Centrum 6 für diagnostische und interventionelle Radiologie und Nuklearmedizin, Charité--Universitätsmedizin Berlin, Germany. juri.ruf@charite.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Artifacts* Female Humans Image Enhancement / methods* Male Middle Aged Neuroendocrine Tumors / diagnosis*, metabolism Radiation Dosage Radiopharmaceuticals / diagnostic use, pharmacokinetics Receptors, Somatostatin / metabolism* Reproducibility of Results Sensitivity and Specificity Somatostatin / analogs & derivatives*, diagnostic use, pharmacokinetics Subtraction Technique Tomography, Emission-Computed, Single-Photon / methods* Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 0/Receptors, Somatostatin; 138661-02-6/pentetreotide; 51110-01-1/Somatostatin |
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