Document Detail


Influence of atorvastatin on blood pressure control in treated hypertensive, normolipemic patients - An open, pilot study.
MedLine Citation:
PMID:  20070250     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: The aim of the study was to determine whether a high dose of atorvastatin lowers blood pressure (BP) in normolipemic patients with well controlled primary arterial hypertension and if this effect is associated with alteration of biomarkers of endothelial function and oxidative stress. In this open-label study, normolipemic patients (n=56) were randomized in the proportion of 2:1 to receive atorvastatin 80 mg daily for 3 months (statin-treated, ST n=39), or to previous therapy (statin-free, SF). BP was measured using a 24-h ambulatory BP measurement device. Plasma levels of 6-keto-PGF(1alpha) (prostacyclin metabolite), serum nitric oxide (NO) and levels of autoantibodies immunoglobulin G against oxidatively modified low-density lipoprotein (ox-LDL) were measured.
MAJOR FINDINGS: The mean change in systolic BP and diastolic BP for ST was - 5.7 mmHg (95% CI -4.1 to -7.2 mmHg) and -3.9 mmHg (95% CI -2.7 to -5.0 mmHg), respectively. Hypotensive statin effect was independent of lipid lowering. No change of BP in SF patients was observed. In ST, prostacyclin metabolites and NO concentrations were not significantly increased and autoantibodies against ox-LDL concentrations did not change. In ST, the decrease in BP correlated with increase in NO and decrease in autoantibodies against ox-LDL.
PRINCIPAL CONCLUSION: High-dose atorvastatin resulted in reduction of BP independently of lipid-lowering effect, changes in endothelial function and oxidative stress, but it was related to the increase in NO and decrease in autoantibodies against ox-LDL. However, because of the open design of the study, these results should be carefully debated.
Authors:
Agnieszka M Kuklinska; Barbara Mroczko; Wlodzimierz J Musial; Robert Sawicki; Anna Kozieradzka; Monika Usowicz-Szarynska; Karol Kaminski; Malgorzata Knapp; Maciej Szmitkowski
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure     Volume:  19     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  England    
Other Details:
Languages:  eng     Pagination:  260-6     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Medical University, Bialystok, Poland. agnieszka.kuklinska@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects
Blood Pressure Monitoring, Ambulatory
Cholesterol / blood
Endothelium, Vascular / drug effects
Female
Heptanoic Acids / therapeutic use*
Humans
Hypertension / blood,  drug therapy*,  physiopathology
Hypolipidemic Agents / therapeutic use*
Lipoproteins, LDL / blood
Male
Middle Aged
Oxidative Stress / drug effects
Pilot Projects
Pyrroles / therapeutic use*
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Heptanoic Acids; 0/Hypolipidemic Agents; 0/Lipoproteins, LDL; 0/Pyrroles; 0/Triglycerides; 110862-48-1/atorvastatin; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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