Document Detail

Influence of atipamezole on effects of midsacral subarachnoidally administered detomidine in mares.
MedLine Citation:
PMID:  9563633     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine effects of atipamezole on detomidine midsacral subarachnoidally-induced analgesia, cardiovascular and respiratory activity, head ptosis, and position of pelvic limbs in healthy mares. ANIMALS: 10 healthy mares. PROCEDURE: Using a randomized, blinded, crossover study design, mares received detomidine (0.03 mg/kg of body weight, diluted in 3 ml of CSF) midsacral subarachnoidally, followed by atipamezole (0.1 mg/kg [test]) or sterile saline (0.9% NaCl) solution (control), i.v. 61 minutes later and saline solution (3 ml, midsacral subarachnoidally) on a separate occasion, at least 2 weeks later. Analgesia was determined by lack of sensory perception to electrical stimulation at the perineal dermatome and no response to needle-prick stimulation extending from the coccygeal to T15 dermatomes. Arterial acid-base (pH, standard bicarbonate, and base excess values), gas tensions (PO2, PCO2), PCV, total solids concentration, heart and respiratory rates, rectal temperature, and arterial blood pressure were determined, and mares were observed for sweating and urination. Mean scores of perineal analgesia, head ptosis, position of pelvic limbs, and cardiovascular and respiratory data were compared for the 3-hour test period. RESULTS: Subarachnoidally administered detomidine induced perineal analgesia (mean +/- SD onset, 9.0 +/- 4.6 minutes; duration, 130 +/- 26 minutes), marked head ptosis, moderate changes in pelvic limb position, cardiovascular and respiratory depression, sweating in analgesic zones, and diuresis. Intravenously administered atipamezole significantly reduced mean scores of detomidine-induced perineal analgesia, head ptosis, pelvic limb position, sweating and diuresis; partially antagonized detomidine-induced bradycardia; and did not effect detomidine-induced bradypnea. CONCLUSIONS AND CLINICAL RELEVANCE: Most effects of midsacral subarachnoidally administered detomidine, except bradycardia and bradypnea, were reversed by atipamezole (0.1 mg/kg, i.v.), indicating that most of the actions of detomidine were mediated via activation of alpha2-adrenergic receptors.
R T Skarda; W W Muir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  59     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-02     Completed Date:  1998-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  468-77     Citation Subset:  IM    
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210-1089, USA.
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MeSH Terms
Acid-Base Equilibrium / drug effects
Adrenergic alpha-Antagonists / pharmacology*
Analgesics / administration & dosage,  pharmacology*
Blood Pressure / drug effects
Body Temperature / drug effects
Cross-Over Studies
Drug Interactions
Electric Stimulation
Heart Rate / drug effects
Imidazoles / administration & dosage,  pharmacology*
Random Allocation
Respiration / drug effects
Sensation / drug effects
Single-Blind Method
Subarachnoid Space
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Analgesics; 0/Imidazoles; 104054-27-5/atipamezole; 76631-46-4/detomidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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