| Influence of atenolol on the relationship between heart rate and QT interval in patients with exercise-induced myocardial ischemia. | |
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MedLine Citation:
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PMID: 1473307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to analyze the relationship between heart rate and QT interval (HR-QT) during exercise in control subjects (Group A) and in patients with coronary artery disease (CAD) with effort angina and without previous myocardial infarction (MI) (Group B). The diagnosis of CAD was confirmed by coronarographic examination. The correlation HR-QT was significant (p < 0.001) in both groups on effort and at recovery. The analysis of the regression HR-QT was carried out separately, both on effort in upright position and at rest in supine position, to avoid the influence of posture on QT length. During effort, the regression line showed lower slope and intercept values in Group B (p < 0.001) than those for Group A. A similar behavior was also observed at rest. Thus, at the highest heart rate, where ECG signs of ischemia (ST depression > 1 mm) frequently occurred, a longer QT interval was present in Group B. Moreover, in Group B, the QT interval in the presence of ECG signs of ischemia was significantly longer (p < 0.01) than in Group A at comparable heart rates both on effort and at rest, thereby confirming the result obtained by comparing both regression lines. The same effort protocol was repeated in Group B patients after acute administration of atenolol 100 mg per os. After atenolol administration, the analysis of the regression HR-QT in Group B clearly showed a shorter QT interval than that obtained in washout period during the baseline test at the highest heart rates where the ECG frequently showed signs of ischemia.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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S Ferraro; G Maddalena; V D'Agosto; M D'Alto; S Fazio; M Santomauro; M Romano; M Chiariello |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 15 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-02-01 Completed Date: 1993-02-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 911-5 Citation Subset: IM |
Affiliation:
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Department of Cardiology and Cardiovascular Surgery, Federico II University, Naples, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Angina Pectoris / physiopathology* Atenolol / administration & dosage, pharmacology* Coronary Disease / physiopathology Electrocardiography / drug effects* Exercise Test Female Heart Rate / drug effects* Humans Male Middle Aged Myocardial Ischemia / physiopathology* Physical Exertion / physiology Regression Analysis |
| Chemical | |
Reg. No./Substance:
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29122-68-7/Atenolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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