| Influence of ascorbic acid on cytotoxic activity of copper and iron ions in vitro. | |
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MedLine Citation:
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PMID: 11243246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated survival of two kinds of human embryonic cells (CLV102, Lu106) and human melanoma cells (Mel8) exposed to exogenous iron and copper ions in the absence or in the presence of ascorbic acid, catalase and superoxide dismutase. Iron ions produced cytotoxicity towards both kinds of cells dependent on its concentration. Catalase suppressed the cytotoxicity induced by iron ions in Lu106 cells. whereas in CLV102 and Mel8 cells, was ineffective. By contrast, superoxide dismutase abolished the cytotoxicity of iron ions towards CLV102 cells, whereas in Lu106 and Mel8 cells, was ineffective. The mixture of iron ions with ascorbic acid was less cytotoxic than iron ions themselves or ascorbic acid itself, only in CLV102 and Lu106 cells. Ascorbic acid enhanced drastically cytotoxic effect of copper ions in all kinds of cells. |
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Authors:
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J Marczewska; J H Koziorowska; E L Anuszewska |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta poloniae pharmaceutica Volume: 57 ISSN: 0001-6837 ISO Abbreviation: Acta Pol Pharm Publication Date: 2000 Nov-Dec |
Date Detail:
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Created Date: 2001-03-12 Completed Date: 2001-04-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985167R Medline TA: Acta Pol Pharm Country: Poland |
Other Details:
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Languages: eng Pagination: 415-8 Citation Subset: IM |
Affiliation:
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Drug Institute, Warsaw, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ascorbic Acid
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pharmacology* Cell Survival / drug effects Cells, Cultured Copper / toxicity* Humans Iron / toxicity* Semen / physiology |
| Chemical | |
Reg. No./Substance:
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50-81-7/Ascorbic Acid; 7439-89-6/Iron; 7440-50-8/Copper |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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