| Influence of ascites on tobramycin pharmacokinetics. | |
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MedLine Citation:
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PMID: 6707233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of ascites on the disposition of tobramycin was examined in eight subjects with cirrhosis of the liver. Five of these subjects had resolution of ascites so they could be used as their own controls. While there was no significant effect of ascites on the clearance and half-life of tobramycin, the volume of distribution of tobramycin was significantly larger when ascites was present, 0.32 versus 0.26 liter/kg (P less than 0.01). There was a trend for the volume of distribution to be larger in those patients with larger ascitic fluid volume. |
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Authors:
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R Sampliner; D Perrier; R Powell; P Finley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 24 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-05-17 Completed Date: 1984-05-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 43-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Ascites / metabolism* Humans Kinetics Male Middle Aged Tobramycin / metabolism* |
| Chemical | |
Reg. No./Substance:
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32986-56-4/Tobramycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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