Document Detail

Influence of artificial fat emulsions on the composition of serum lipoproteins in humans.
MedLine Citation:
PMID:  3080868     Owner:  NLM     Status:  MEDLINE    
Infusions of about 50 g soya oil, emulsified with egg lecithin (Intralipid) or soya lecithin (Lipofundin) have different effects on the composition of serum lipoprotein fractions in volunteers (n = 6). Triglycerides are altered in all lipoprotein fractions most in lowest density classes but also in LDL and HDL. Differences in maximal concentrations (higher during Intralipid) and differences in removal rate of triglycerides (faster with Lipofundin) are due to different emulsifiers. Cholesterol increase in VLDL and decrease in HDL3 are independent from emulsifier. Intralipid produces an increase of phospholipids in all lipoprotein fractions, Lipofundin only in VLDL. Linoleic acid in lecithin fatty acids of lipoprotein fractions is increased by Lipofundin and decreased by Intralipid. Apolipoprotein A-I and A-II decrease in HDL3 and slightly increase in HDL2. During both infusions apolipoprotein C-II increases significantly after Intralipid.
S Hailer; G Wolfram
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  43     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-03-10     Completed Date:  1986-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  225-33     Citation Subset:  AIM; IM    
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MeSH Terms
Apolipoprotein A-I
Apolipoprotein A-II
Apolipoprotein C-II
Apolipoprotein C-III
Apolipoproteins A / blood
Apolipoproteins B / blood
Apolipoproteins C / blood
Cholesterol / blood
Drug Combinations / pharmacology
Fat Emulsions, Intravenous / pharmacology*
Lipoproteins / blood*
Lipoproteins, HDL / blood
Lipoproteins, LDL / blood
Lipoproteins, VLDL / blood
Middle Aged
Phospholipids / blood,  pharmacology
Sorbitol / pharmacology
Triglycerides / blood
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Apolipoprotein A-II; 0/Apolipoprotein C-II; 0/Apolipoprotein C-III; 0/Apolipoproteins A; 0/Apolipoproteins B; 0/Apolipoproteins C; 0/Drug Combinations; 0/Fat Emulsions, Intravenous; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 0/Phospholipids; 0/Triglycerides; 11096-66-5/Lipofundin; 50-70-4/Sorbitol; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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