| Influence of arterial hypertension and diet-induced atherosclerosis on macular drusen. | |
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MedLine Citation:
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PMID: 12605267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate whether development of macular drusen is influenced by experimentally induced chronic arterial hypertension and atherosclerosis. METHODS: The prospective experimental study included 93 eyes of 51 elderly rhesus monkeys. The total study group was divided into groups with experimental arterial hypertension ( n=22), diet-induced atherosclerosis ( n=10), or both arterial hypertension and atherosclerosis ( n=29) and a control group without arterial hypertension or atherosclerosis ( n=32). Using color wide-angle fundus photographs taken at the beginning and the end of the study, age-related macular degeneration was graded by counting the number and estimating the mean size of drusen in the macular region. RESULTS: In the monkeys with arterial hypertension, the count and area of the macular drusen and the change in number and size of macular drusen during the follow-up period were significantly ( P<0.05) higher than in the monkeys of the control group. Correspondingly, the count and size of macular drusen were significantly ( P<0.05) correlated with the duration of arterial hypertension. In contrast, monkeys with only atherosclerosis did not vary significantly ( P>0.10) from monkeys of the control group in number and size of drusen. The macular drusen parameters were statistically ( P>0.20) independent of the duration of atherosclerosis. Similarly, the atherosclerotic monkeys and the monkeys of the control group did not vary significantly ( P>0.30) in the change of the macular drusen parameters during the follow-up period. CONCLUSIONS: Development of macular drusen as part of age-related macular degeneration in rhesus monkeys may be associated with experimentally induced arterial hypertension. It does not seem to be influenced by diet-induced atherosclerosis. |
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Authors:
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Jost B Jonas; Sohan Singh Hayreh; Peter Martus |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2003-01-29 |
Journal Detail:
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Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Volume: 241 ISSN: 0721-832X ISO Abbreviation: Graefes Arch. Clin. Exp. Ophthalmol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-02-26 Completed Date: 2003-04-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8205248 Medline TA: Graefes Arch Clin Exp Ophthalmol Country: Germany |
Other Details:
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Languages: eng Pagination: 125-34 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Faculty of Clinical Medicine Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriosclerosis / complications* Diet, Atherogenic Hypertension, Renovascular / complications* Macaca mulatta Macula Lutea / pathology* Macular Degeneration / etiology, pathology Prospective Studies Retinal Drusen / etiology*, pathology Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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EY-1576/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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