Document Detail


Influence of arterial hypertension and diet-induced atherosclerosis on macular drusen.
MedLine Citation:
PMID:  12605267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate whether development of macular drusen is influenced by experimentally induced chronic arterial hypertension and atherosclerosis. METHODS: The prospective experimental study included 93 eyes of 51 elderly rhesus monkeys. The total study group was divided into groups with experimental arterial hypertension ( n=22), diet-induced atherosclerosis ( n=10), or both arterial hypertension and atherosclerosis ( n=29) and a control group without arterial hypertension or atherosclerosis ( n=32). Using color wide-angle fundus photographs taken at the beginning and the end of the study, age-related macular degeneration was graded by counting the number and estimating the mean size of drusen in the macular region. RESULTS: In the monkeys with arterial hypertension, the count and area of the macular drusen and the change in number and size of macular drusen during the follow-up period were significantly ( P<0.05) higher than in the monkeys of the control group. Correspondingly, the count and size of macular drusen were significantly ( P<0.05) correlated with the duration of arterial hypertension. In contrast, monkeys with only atherosclerosis did not vary significantly ( P>0.10) from monkeys of the control group in number and size of drusen. The macular drusen parameters were statistically ( P>0.20) independent of the duration of atherosclerosis. Similarly, the atherosclerotic monkeys and the monkeys of the control group did not vary significantly ( P>0.30) in the change of the macular drusen parameters during the follow-up period. CONCLUSIONS: Development of macular drusen as part of age-related macular degeneration in rhesus monkeys may be associated with experimentally induced arterial hypertension. It does not seem to be influenced by diet-induced atherosclerosis.
Authors:
Jost B Jonas; Sohan Singh Hayreh; Peter Martus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-01-29
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  241     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-26     Completed Date:  2003-04-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  125-34     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Faculty of Clinical Medicine Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteriosclerosis / complications*
Diet, Atherogenic
Hypertension, Renovascular / complications*
Macaca mulatta
Macula Lutea / pathology*
Macular Degeneration / etiology,  pathology
Prospective Studies
Retinal Drusen / etiology*,  pathology
Risk Factors
Grant Support
ID/Acronym/Agency:
EY-1576/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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