| Influence of arterial hypertension on colonic healing in rats. | |
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MedLine Citation:
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PMID: 22850701 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: Evaluation of colonic healing in spontaneously hypertensive rats. METHODS: Fifty male, young and inbred rats were used. Twenty-five Wistar Kyoto rats (WKY) as control and twenty-five spontaneously hypertensive rats (SHR) as an experimental group. Colotomy and bowel suture at 2.5 cm from the peritoneal reflection were performed. All animals were allocated randomly into sub-groups for review at the third, seventh and fourteenth days after surgery. We evaluated the concentration of angiotensin II, the burst pressure, epithelialization, the organization of the tunics of the bowel wall, inflammatory response and collagen deposition. RESULTS: The burst pressure, epithelialization, organization of the tunics and collagen deposition was not significant between groups. The inflammatory reaction was more intense in the control group on the third postoperative day (p=0.023) as the experimental group on the remaining time. CONCLUSION: Systemic arterial hypertension in rats did not influence significantly the healing process of colonic anastomoses. |
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Authors:
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Gilberto Luiz Ortolan; Maria de Lourdes Pessole Biondo-Simões; Giovani Marino Fávero; Daniel Fernandes; Mário Rodrigues Montemór Netto; Luiz Renato Olchanheski |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia Volume: 27 ISSN: 1678-2674 ISO Abbreviation: Acta Cir Bras Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-08-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9103983 Medline TA: Acta Cir Bras Country: Brazil |
Other Details:
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Languages: eng Pagination: 515-21 Citation Subset: IM |
Affiliation:
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Department of Surgery, PUCPR. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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