Document Detail

Influence of arachidonic acid metabolites on cardiac alpha 1-adrenoceptor responses in diabetic rats.
MedLine Citation:
PMID:  1330257     Owner:  NLM     Status:  MEDLINE    
There is evidence that one or more metabolites of arachidonic acid can produce positive inotropic effects and may also be implicated in the enhanced alpha 1-adrenoceptor responses in hearts from diabetic rats. We therefore carried out a study to investigate the possibility that arachidonic acid metabolites could be involved in the altered cardiac alpha 1-effect of norepinephrine (in the presence of propranolol) in chronic streptozotocin-diabetic rats. Our results have shown that in the presence of the cyclooxygenase inhibitor indomethacin or the thromboxane synthetase inhibitor imidazole, the norepinephrine-stimulated positive inotropic effect and the formation of inositol 1,4,5-trisphosphate were significantly increased in control hearts but were unaltered in hearts from diabetic rats. The addition of the prostacyclin synthetase inhibitor tranylcypromine reduced the norepinephrine-stimulated positive inotropic effect and inositol 1,4,5-trisphosphate formation only in diabetic hearts and had no effect in the controls. The nature and physiological significance of the enhanced positive inotropic effect and inositol 1,4,5-trisphosphate formation in the control heart with the addition of indomethacin and imidazole are still unclear. The effect of tranylcypromine may indicate the participation of prostacyclin in mediating the enhanced alpha 1-inotropic effect of norepinephrine in the chronic diabetic heart.
H Xiang; J H McNeill
Related Documents :
15120707 - Diabetic rats treated by low molecular weight heparin op 2123/parnaparin: morphological...
8788307 - Improvement of cardiac performance and metabolism in long-term diabetes mellitus after ...
19892057 - Findings from left ventricular strain and strain rate imaging in asymptomatic patients ...
15095247 - Allometric relationship of postmolt net ion uptake, ventilation, and circulation in the...
21860247 - Pre- and postnatal methyl deficiency in the rat differentially alters glucose homeostasis.
10099967 - Evaluation of hypothalamic-pituitary-adrenal axis in amenorrhoeic women with insulin-de...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  70     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-12-23     Completed Date:  1992-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  680-6     Citation Subset:  IM    
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arachidonic Acids / metabolism,  pharmacology*
Blood Glucose / metabolism
Diabetes Mellitus, Experimental / metabolism*,  physiopathology
Heart / drug effects*
Imidazoles / pharmacology
Inosine Triphosphate / pharmacology
Myocardial Contraction / physiology
Norepinephrine / pharmacology
Propranolol / pharmacology
Rats, Wistar
Receptors, Adrenergic, alpha / drug effects,  metabolism*
Thromboxane-A Synthase / antagonists & inhibitors
Tranylcypromine / pharmacology
Reg. No./Substance:
0/Arachidonic Acids; 0/Blood Glucose; 0/Imidazoles; 0/Receptors, Adrenergic, alpha; 132-06-9/Inosine Triphosphate; 155-09-9/Tranylcypromine; 288-32-4/imidazole; 51-41-2/Norepinephrine; 525-66-6/Propranolol; EC Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Indomethacin worsens and a leukotriene biosynthesis inhibitor accelerates mucosal healing in rat col...
Next Document:  Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl...