Document Detail


Influence of arachidonic acid metabolites on cardiac alpha 1-adrenoceptor responses in diabetic rats.
MedLine Citation:
PMID:  1330257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is evidence that one or more metabolites of arachidonic acid can produce positive inotropic effects and may also be implicated in the enhanced alpha 1-adrenoceptor responses in hearts from diabetic rats. We therefore carried out a study to investigate the possibility that arachidonic acid metabolites could be involved in the altered cardiac alpha 1-effect of norepinephrine (in the presence of propranolol) in chronic streptozotocin-diabetic rats. Our results have shown that in the presence of the cyclooxygenase inhibitor indomethacin or the thromboxane synthetase inhibitor imidazole, the norepinephrine-stimulated positive inotropic effect and the formation of inositol 1,4,5-trisphosphate were significantly increased in control hearts but were unaltered in hearts from diabetic rats. The addition of the prostacyclin synthetase inhibitor tranylcypromine reduced the norepinephrine-stimulated positive inotropic effect and inositol 1,4,5-trisphosphate formation only in diabetic hearts and had no effect in the controls. The nature and physiological significance of the enhanced positive inotropic effect and inositol 1,4,5-trisphosphate formation in the control heart with the addition of indomethacin and imidazole are still unclear. The effect of tranylcypromine may indicate the participation of prostacyclin in mediating the enhanced alpha 1-inotropic effect of norepinephrine in the chronic diabetic heart.
Authors:
H Xiang; J H McNeill
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  70     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-12-23     Completed Date:  1992-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  680-6     Citation Subset:  IM    
Affiliation:
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acids / metabolism,  pharmacology*
Blood Glucose / metabolism
Diabetes Mellitus, Experimental / metabolism*,  physiopathology
Heart / drug effects*
Imidazoles / pharmacology
Inosine Triphosphate / pharmacology
Male
Myocardial Contraction / physiology
Norepinephrine / pharmacology
Propranolol / pharmacology
Rats
Rats, Wistar
Receptors, Adrenergic, alpha / drug effects,  metabolism*
Thromboxane-A Synthase / antagonists & inhibitors
Tranylcypromine / pharmacology
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Blood Glucose; 0/Imidazoles; 0/Receptors, Adrenergic, alpha; 132-06-9/Inosine Triphosphate; 155-09-9/Tranylcypromine; 288-32-4/imidazole; 51-41-2/Norepinephrine; 525-66-6/Propranolol; EC 5.3.99.5/Thromboxane-A Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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