Document Detail

Influence of apolipoprotein-E phenotypes on postprandial lipoprotein metabolism after three different fat loads.
MedLine Citation:
PMID:  11448569     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the postprandial response to three fat-loading tests in healthy subjects with different apolipoprotein E (apoE) phenotypes. Thirty-four subjects were studied: 15 with apoE3/3 (7 men and 8 women), 12 with apoE4/3 (5 men and 7 women), and 7 with apoE2/3 (4 men and 3 women). All received three oral fat loads at 1-wk intervals in meals rich in monounsaturated fatty acid, polyunsaturated fatty acid, and saturated fatty acid, with retinyl palmitate (60000 IU/m(2) of aqueous vitamin A) to quantify lipoproteins secreted by the intestine. No significant differences in postprandial lipoproteins were found between the three different fat loads. Peaks and incremental areas under the curve of retinyl palmitate in non-chylomicron fractions were higher in the apoE2/3- than in the apoE3/3- and apoE4/3-phenotype groups in meals rich in monounsaturated and polyunsaturated fatty acids (P < 0.05). When the three fat loads were analyzed together, the incremental area under the curve of retinyl palmitate was much higher in the apoE2/3- than in the other apoE-phenotype groups (P = 0.0004). In conclusion, the magnitude of intestinal lipoproteins after fat load, especially with monosaturated and polyunsaturated fatty acids, is higher in subjects with apoE2/3 than in those with apoE3/3 and apoE4/3 phenotypes.
C Fernández-Miranda; P Cancelas; M Sanz; A Porres; J Gámez Gerique
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  17     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    2001 Jul-Aug
Date Detail:
Created Date:  2001-07-12     Completed Date:  2002-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  529-33     Citation Subset:  IM    
Service of Internal Medicine, Lipids Unit, Hospital Universitario 12 de Octubre, Madrid, Spain.
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MeSH Terms
Apolipoproteins E / classification,  genetics,  metabolism*
Area Under Curve
Dietary Fats / administration & dosage*,  metabolism
Fatty Acids / administration & dosage,  metabolism
Fatty Acids, Monounsaturated / administration & dosage,  metabolism
Fatty Acids, Unsaturated / administration & dosage,  metabolism
Lipoproteins / metabolism*
Polymorphism, Genetic
Postprandial Period / physiology*
Time Factors
Vitamin A / analogs & derivatives*,  diagnostic use
Reg. No./Substance:
0/Apolipoproteins E; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Unsaturated; 0/Lipoproteins; 11103-57-4/Vitamin A; 79-81-2/retinol palmitate

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