Document Detail


Influence of apolipoprotein-E phenotypes on postprandial lipoprotein metabolism after three different fat loads.
MedLine Citation:
PMID:  11448569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to evaluate the postprandial response to three fat-loading tests in healthy subjects with different apolipoprotein E (apoE) phenotypes. Thirty-four subjects were studied: 15 with apoE3/3 (7 men and 8 women), 12 with apoE4/3 (5 men and 7 women), and 7 with apoE2/3 (4 men and 3 women). All received three oral fat loads at 1-wk intervals in meals rich in monounsaturated fatty acid, polyunsaturated fatty acid, and saturated fatty acid, with retinyl palmitate (60000 IU/m(2) of aqueous vitamin A) to quantify lipoproteins secreted by the intestine. No significant differences in postprandial lipoproteins were found between the three different fat loads. Peaks and incremental areas under the curve of retinyl palmitate in non-chylomicron fractions were higher in the apoE2/3- than in the apoE3/3- and apoE4/3-phenotype groups in meals rich in monounsaturated and polyunsaturated fatty acids (P < 0.05). When the three fat loads were analyzed together, the incremental area under the curve of retinyl palmitate was much higher in the apoE2/3- than in the other apoE-phenotype groups (P = 0.0004). In conclusion, the magnitude of intestinal lipoproteins after fat load, especially with monosaturated and polyunsaturated fatty acids, is higher in subjects with apoE2/3 than in those with apoE3/3 and apoE4/3 phenotypes.
Authors:
C Fernández-Miranda; P Cancelas; M Sanz; A Porres; J Gámez Gerique
Related Documents :
16935699 - Apolipoprotein e enrichment of immuno-separated chylomicron and chylomicron remnants fo...
8561069 - N-3 fatty acids do not enhance ldl susceptibility to oxidation in hypertriacylglycerole...
2808549 - Contribution of endosomes to intrahepatic distribution of apolipoprotein b and apolipop...
20411679 - Lipid profiles and trans fatty acids in serum phospholipids of semi-nomadic fulani in n...
10366779 - Incorporation of esterified soybean isoflavones with antioxidant activity into low dens...
2022079 - Role of non-esterified fatty acids in regulating plasma cholesterol transport.
24723079 - Association of dietary, circulating, and supplement fatty acids with coronary risk: a s...
24767069 - Nutritional quality of grains of sorghum cultivar grown under different levels of micro...
15363509 - (s)-nitroxycarnitine nitrate production from (s)-carnitine by using acetic anhydride/ni...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  17     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    2001 Jul-Aug
Date Detail:
Created Date:  2001-07-12     Completed Date:  2002-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  529-33     Citation Subset:  IM    
Affiliation:
Service of Internal Medicine, Lipids Unit, Hospital Universitario 12 de Octubre, Madrid, Spain. cfdezmirp@medynet.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Apolipoproteins E / classification,  genetics,  metabolism*
Area Under Curve
Dietary Fats / administration & dosage*,  metabolism
Fatty Acids / administration & dosage,  metabolism
Fatty Acids, Monounsaturated / administration & dosage,  metabolism
Fatty Acids, Unsaturated / administration & dosage,  metabolism
Female
Humans
Lipoproteins / metabolism*
Male
Phenotype
Polymorphism, Genetic
Postprandial Period / physiology*
Time Factors
Vitamin A / analogs & derivatives*,  diagnostic use
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Unsaturated; 0/Lipoproteins; 11103-57-4/Vitamin A; 79-81-2/retinol palmitate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Parasitic screening of a refugee population in Illinois.
Next Document:  Fat-free and fat mass percentiles in 5225 healthy subjects aged 15 to 98 years.