Document Detail


Influence of antidiuretic hormone on intrarenal blood flow distribution in diabetes insipidus dogs and rats.
MedLine Citation:
PMID:  1257256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution of labeled microspheres within the renal cortex was used to evaluate the influence of physiological amounts of antidiuretic hormone on intrarenal blood flow distribution in hypophysectomized dogs and in rats with hereditary diabetes insipidus. In both species, intravenous infusions of ADH caused a significant decrease in the ratio of inner to outer cortical blood flow. The change in blood flow distribution observed in the hypophysectomized dog with ADH was primarily a consequence of a decrease in inner cortical blood flow. No consistent changes in outer cortical blood flow were found. Also in the dog, glomerular filtration rates and electrolyte excretion rates (Na and K) increased following ADH. In contrast, ADH infusion into Brattleboro rats caused no change in glomerular filtration or excretion of Na and K.
Authors:
R O Banks; J Di Salvo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  151     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-06-02     Completed Date:  1976-06-02     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  547-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Insipidus / physiopathology*
Dogs
Female
Hypophysectomy
Kidney / blood supply*
Kidney Cortex / blood supply
Male
Natriuresis / drug effects
Potassium / urine
Rats
Regional Blood Flow / drug effects
Vasopressins / pharmacology*
Chemical
Reg. No./Substance:
11000-17-2/Vasopressins; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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