| Influence of anti-rheumatic drugs on gut permeability and on the gut associated lymphoid tissue. | |
| | |
MedLine Citation:
|
PMID: 8674146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
There is great interest in the association between intestinal inflammation and the various arthropathies. However, most studies assessing intestinal function in these diseases are confounded by the fact that non-steroidal anti-inflammatory drugs (NSAIDs) have profound effects on the small intestine. Hence NSAIDs cause quite distinct and severe biochemical damage during drug absorption (uncoupling of mitochondrial oxidative phosphorylation proving to be most important) which results in increased intestinal permeability. All commonly used NSAIDs, apart from aspirin and nabumetone, are associated with increased intestinal permeability in man. Whilst reversible in the short term, it may take months to improve following prolonged NSAID use. Increased intestinal permeability appears to be the central mechanism of converting the biochemical damage to an inflammatory tissue reaction (NSAID enteropathy). The inflammatory enteropathy is not, however, unique to NSAIDs but similar changes are found with other permeability breakers. In intestinal infections and in diseases associated with reduced mucosal defence, suggesting that the small intestinal inflammation represents a common final pathway for a number of intestinal injuries. Spondylarthropathies are associated with a high prevalence of terminal ileitis, but as most patients have been receiving NSAIDs it has been difficult to dissociate the effects of NSAIDs on intestinal function from that of the ileitis itself. Nevertheless, two studies suggest that increased intestinal permeability in spondylarthropathies occur independently of NSAID ingestion. Whilst these findings may have implications for the development of arthritis, the permeability changes in spondylarthropathy do not differ quantitatively or qualitatively from that of NSAIDs or other permeability breakers. NSAID enteropathy can be differentiated from spondylarthropathic enteropathy by differences in location of disease and lack of predilection of certain HLA types. However, as the two may coexist both enteroscopy and ileocolonoscopy may be necessary for this distinction. |
| | |
Authors:
|
I Bjarnason; T J Peters |
Related Documents
:
|
16253506 - Leaky guts and lipid rafts. 9497976 - Crohn's disease presenting with acute colonic perforation. 21476446 - Does mosquito control have an effect on mosquito-borne disease? the case of ross river ... 2200576 - Surgery of the bovine large intestine. 11429666 - Infliximab for the treatment of crohn's disease: review and indications for clinical us... 11392526 - 31phosphorus magnetic resonance spectroscopy in late-onset tay-sachs disease. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Baillière's clinical rheumatology Volume: 10 ISSN: 0950-3579 ISO Abbreviation: Baillieres Clin Rheumatol Publication Date: 1996 Feb |
Date Detail:
|
Created Date: 1996-08-09 Completed Date: 1996-08-09 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 8805770 Medline TA: Baillieres Clin Rheumatol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 165-76 Citation Subset: IM |
Affiliation:
|
Department of Clinical Biochemistry, King's College School of Medicine & Dentistry, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-Inflammatory Agents, Non-Steroidal / pharmacology*, toxicity Humans Intestinal Absorption / drug effects* Intestine, Small / drug effects* Lymphoid Tissue / drug effects* Permeability / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents, Non-Steroidal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Course of gut inflammation in spondylarthropathies and therapeutic consequences.
Next Document: The gut associated addressins: lymphocyte homing in the gut.