| Influence of anti-inflammatory and vasoactive drugs on microcirculation and angiogenesis after burn in mice. | |
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MedLine Citation:
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PMID: 21334823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The treatment of burns remains a challenge. Besides the administration of physiological saline, local disinfection and symptomatic medications, no causal therapy is known to accelerate angiogenesis and wound healing. The aim of this study was to investigate the influences of dilatative and anti-inflammatory acting drugs on microcirculation, angiogenesis and leukocyte behavior, which had shown positive effects in former burn studies. METHODS: The ears of male hairless mice (n=47) were inflicted with full thickness burns using a hot air jet. Then the affects of five intraperitoneal injections of either acetylsalicylic acid (ASA), isosorbide dinitrate, prostaglandin E1 (PGE1) or sodium chloride (each administered to one of four corresponding study groups), on microcirculation, leukocyte-endothelial interaction and angiogenesis were investigated over a 12 day period using intravital fluorescent microscopy. RESULTS: Angiogenesis was slightly improved by PGE1 (0.3 vs. 1.3% non-perfused area in other groups on day 12, p=0.029). Additionally, blood flow increased and rolling leukocytes decreased compared to other groups. The ASA-group showed best functional vessel density and lowest leukocyte-adhesion. The often described posttraumatic expansion of tissue damage could not be observed in either group. CONCLUSION: Prostaglandin E1 improved angiogenesis, increased the blood flow and reduced the number of rolling leukocytes. ASA had positive influences on functional vessel density, edema formation and the number of sticking leukocytes. However, it reduced the blood flow. Overall, out of all the drugs tested, prostaglandin seems to have the greatest positive impact on microcirculation and angiogenesis in burns. |
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Authors:
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O Goertz; A Ring; B Buschhaus; T Hirsch; A Daigeler; L Steinstraesser; H-U Steinau; S Langer |
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Publication Detail:
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Type: Journal Article Date: 2011-02-22 |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 37 ISSN: 1879-1409 ISO Abbreviation: Burns Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-04-22 Completed Date: 2011-07-22 Revised Date: 2011-10-27 |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: Netherlands |
Other Details:
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Languages: eng Pagination: 656-64 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd and ISBI. All rights reserved. |
Affiliation:
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Department of Plastic and Hand Surgery, Burn Center, BG-University Hospital Bergmannsheil, Ruhr-University Bochum, Bochum, Germany. ole.goertz@rub.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / pharmacology* Aspirin / analogs & derivatives, pharmacology Burns / drug therapy*, physiopathology Disease Models, Animal Endothelium / pathology Injections, Intraperitoneal Isosorbide / analogs & derivatives, pharmacology Leukocytes / pathology Mice Mice, Hairless Microcirculation / drug effects* Neovascularization, Pathologic / drug therapy* Prostaglandins / pharmacology Skin / blood supply*, pathology Sodium Chloride / pharmacology Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Prostaglandins; 0/Vasodilator Agents; 0/isosorbide diaspirinate; 50-78-2/Aspirin; 652-67-5/Isosorbide; 7647-14-5/Sodium Chloride |
| Comments/Corrections | |
Comment In:
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Burns. 2011 Nov;37(7):1272; author reply 1272-3
[PMID:
21821361
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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