Document Detail

Influence of anti-inflammatory drugs on the interaction of lymphocytes and macrophages.
MedLine Citation:
PMID:  7270338     Owner:  NLM     Status:  MEDLINE    
The helper function of macrophages in lymphocyte stimulation is well known, but there are indications that macrophages may also exert a suppressor effect on lymphocytes. This effect might be due to prostaglandins secreted by the macrophages. In order to test this hypothesis anti-inflammatory drugs, some of which are known inhibitors of prostaglandin synthesis, were added to a series of phytohaemagglutinin (PHA)-stimulated lymphocyte cultures containing different proportions of macrophages and lymphocytes. The experiments showed that high concentrations of all drugs were inhibitory. Moderate concentrations of some of the PG-synthesis-inhibiting drugs (like indomethacin and mefenamic acid), however, appeared to have a stimulatory effect. The stimulation was more pronounced in cultures containing a high proportion of macrophages. These results support the assumption that macrophages release prostaglandins, which suppress PHA-induced lymphocyte proliferation.
H Mullink; M von Blomberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Agents and actions     Volume:  10     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-10-29     Completed Date:  1981-10-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  512-5     Citation Subset:  IM    
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MeSH Terms
Anti-Inflammatory Agents / pharmacology*
Cell Communication / drug effects*
Guinea Pigs
Lymphocyte Activation / drug effects
Lymphocytes / drug effects*
Macrophages / drug effects*,  metabolism
Phytohemagglutinins / pharmacology
Prostaglandins / metabolism
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Phytohemagglutinins; 0/Prostaglandins

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