Document Detail


Influence of antenatal steroids and sex on maturation of the epidermal barrier in the preterm infant.
MedLine Citation:
PMID:  10952704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The epidermal barrier is well developed in term infants but defective in the immature infant with important clinical consequences. The development of the barrier shares similarities with production of pulmonary surfactant. Studies in the rat have shown that barrier maturation is accelerated by antenatal steroids, both structurally and functionally. Females have a more mature barrier than males at the same gestational age. These factors have not been studied in the human. AIM: To examine the influence of antenatal steroids and sex on maturation of the epidermal barrier in the preterm infant. SUBJECTS: A total of 137 infants born before 34 weeks gestation, 80 boys and 57 girls, were studied: 87 had been exposed to antenatal steroids, and 50 had not; 99 were studied prospectively, and 38 had been studied previously. METHOD: Barrier function was measured as transepidermal water loss from abdominal skin by evaporimetry. Measurements were made within the first 48 hours and corrected to a standard relative humidity of 50% (TEWL(50)). RESULTS: The relation between TEWL(50) and gestation was exponential with very high levels in the most immature infants. No influence of antenatal steroids or sex could be shown. When infants who were optimally exposed to antenatal steroids were considered alone, no effect could be shown. CONCLUSION: Epidermal maturation in the preterm infant does not appear to be influenced by antenatal steroids or sex, suggesting that the mechanism of maturation differs from that of the rat.
Authors:
A Jain; N Rutter; P H Cartlidge
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  83     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-09-28     Completed Date:  2000-09-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F112-6     Citation Subset:  AIM; IM    
Affiliation:
Academic Division of Child Health, Nottingham City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK.
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MeSH Terms
Descriptor/Qualifier:
Dexamethasone / therapeutic use*
Epidermis / drug effects,  growth & development*
Female
Glucocorticoids / therapeutic use*
Humans
Infant, Newborn
Infant, Premature / physiology*
Male
Pregnancy
Prenatal Exposure Delayed Effects
Prospective Studies
Retrospective Studies
Sex*
Water Loss, Insensible / physiology
Chemical
Reg. No./Substance:
0/Glucocorticoids; 50-02-2/Dexamethasone
Comments/Corrections

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