| Influence of angiotensin-converting enzyme I/D gene polymorphism on the right ventricular myocardial performance index in patients with a first acute anterior myocardial infarction. | |
MedLine Citation:
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PMID: 15671615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The genetic influence on the myocardial performance index is uncertain, so the aim of the present study was to determine the effects of polymorphism of the angiotensin-converting enzyme (ACE) gene on the right ventricular myocardial performance index (RVMPI) after a first acute anterior myocardial infarction (MI). METHODS AND RESULTS: The subjects were 116 patients with a first acute anterior MI. Based on the polymorphism of the ACE gene, they were classified into 3 groups: deletion/deletion (DD) genotype (group 1, n=45), insertion/deletion (ID) genotype (group 2, n=58), insertion/insertion (II) genotype (group 3, n=13). Echocardiograms were used to determine the RVMPI, left ventricular myocardial performance index (LVMPI), tricuspid E/A, tricuspid deceleration time and the left ventricular diameter diastolic and diameter systolic (LVDd and LVDs). RVMPI and LVMPI were significantly higher in the ACE DD group. Tricuspid E/A, DT, LVDd and LVDs showed no differences among the 3 groups. CONCLUSION: The ID polymorphism of the ACE gene may affect RVMPI and LVMPI after a first acute anterior MI. |
Authors:
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Onder Ozturk; Mehmet S Ulgen; Selahattin Tekes; Unal Ozturk; Nizamettin Toprak |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 69 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-26 Completed Date: 2005-08-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 211-5 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey. droozturk21@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged DNA Mutational Analysis Electrocardiography Female Humans Male Middle Aged Mutagenesis, Insertional Myocardial Infarction / genetics*, physiopathology Peptidyl-Dipeptidase A / genetics* Polymorphism, Genetic* Sequence Deletion Ventricular Dysfunction, Left / genetics Ventricular Dysfunction, Right / genetics* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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