Document Detail


Influence of angiotensin-converting enzyme I/D gene polymorphism on the right ventricular myocardial performance index in patients with a first acute anterior myocardial infarction.
MedLine Citation:
PMID:  15671615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The genetic influence on the myocardial performance index is uncertain, so the aim of the present study was to determine the effects of polymorphism of the angiotensin-converting enzyme (ACE) gene on the right ventricular myocardial performance index (RVMPI) after a first acute anterior myocardial infarction (MI). METHODS AND RESULTS: The subjects were 116 patients with a first acute anterior MI. Based on the polymorphism of the ACE gene, they were classified into 3 groups: deletion/deletion (DD) genotype (group 1, n=45), insertion/deletion (ID) genotype (group 2, n=58), insertion/insertion (II) genotype (group 3, n=13). Echocardiograms were used to determine the RVMPI, left ventricular myocardial performance index (LVMPI), tricuspid E/A, tricuspid deceleration time and the left ventricular diameter diastolic and diameter systolic (LVDd and LVDs). RVMPI and LVMPI were significantly higher in the ACE DD group. Tricuspid E/A, DT, LVDd and LVDs showed no differences among the 3 groups. CONCLUSION: The ID polymorphism of the ACE gene may affect RVMPI and LVMPI after a first acute anterior MI.
Authors:
Onder Ozturk; Mehmet S Ulgen; Selahattin Tekes; Unal Ozturk; Nizamettin Toprak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  69     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-26     Completed Date:  2005-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  211-5     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey. droozturk21@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Aged
DNA Mutational Analysis
Electrocardiography
Female
Humans
Male
Middle Aged
Mutagenesis, Insertional
Myocardial Infarction / genetics*,  physiopathology
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic*
Sequence Deletion
Ventricular Dysfunction, Left / genetics
Ventricular Dysfunction, Right / genetics*
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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