| Influence of anatomical location on arterial thrombosis. | |
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MedLine Citation:
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PMID: 11834539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atherosclerosis manifests as a systemic disease with near global involvement of the named segments of the arterial tree. Acute thrombotic arterial occlusion, however, is not equally distributed. To evaluate intra-individual regional differences in arterial thrombogenicity, we compared (111)In-platelet deposition in porcine carotid and femoral arteries after a standardized crush injury. Within the unidirectional flow conditions of elastic carotid arteries, platelet deposition was more than 3-fold higher compared with predominantly muscular femoral arteries with triphasic arterial flow. To determine the influence of rheology on platelet deposition after crush injury, carotid arteries were transplanted into the femoral position and compared with the paired native carotid and femoral arteries. Similarly, femoral arteries transposed to the carotid position were compared with the paired native carotid artery. In each of these experiments, arterial transposition to a new anatomic location imparts a predilection for platelet deposition indigenous to the new location. In the controlled environment of two high-shear thrombin-independent and -dependent flow chambers, porcine carotid and femoral arterial substrates were indistinguishable from one another with respect to platelet deposition. Regional differences in arterial hemodynamics may account for substantial differences in thrombosis arising from deep arterial injury. |
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Authors:
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Krzysztof Karnicki; Erzsebet Komorowicz; David N Fass; Whyte G Owen; Robert D McBane |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 22 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-08 Completed Date: 2002-02-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 342-7 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Medicine, Mayo Clinic and Foundation for Education and Research, Rochester, MN 55905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / injuries, physiopathology*, ultrasonography Carotid Arteries / transplantation Compliance Female Femoral Artery / injuries, transplantation Hemodynamics* Platelet Activation* Regional Blood Flow Swine Thrombosis / etiology, physiopathology*, ultrasonography* Wounds, Nonpenetrating / complications, physiopathology, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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