Document Detail


Influence of aminophylline and ketotifen in comparison to the lipoxygenase inhibitors NDGA and esculetin and the PAF antagonists WEB 2170 [correction of 2107] and BN 52021 on endothelin-1 induced vaso- and bronchoconstriction.
MedLine Citation:
PMID:  1808625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Theophylline (p less than 0.05) and ketotifen (p greater than 0.05) markedly reduced, but the lipoxygenase inhibitors and PAF receptor antagonists were without any influence on the endothelin-1 (ET-1 1 nmol/kg i.v.) induced increase of pulmonary inflation pressure of anaesthetised and ventilated guinea-pigs. The ET-1 induced increase in mean arterial blood pressure as well as the secondary TXB2 release into bronchoalveolar lavage fluid or plasma was not decreased. TXB2 release cannot be the only mechanism of bronchopulmonary ET-1 effects in guinea-pigs in vivo.
Authors:
G Lueddeckens; K Becker; R Rappold; W Förster
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  44     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-05-21     Completed Date:  1992-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
Affiliation:
Martin Luther-University Halle-Wittenberg, School of Medicine, Department of Pharmacology and Toxicology, Germany.
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MeSH Terms
Descriptor/Qualifier:
Aminophylline / pharmacology*
Animals
Azepines / pharmacology
Bronchoalveolar Lavage Fluid / metabolism
Bronchoconstriction / drug effects*
Bronchoconstrictor Agents / pharmacology
Diterpenes*
Endothelins / pharmacology*
Ginkgolides
Guinea Pigs
Ketotifen / pharmacology*
Lactones / pharmacology
Lipoxygenase Inhibitors / pharmacology*
Lung / blood supply,  drug effects
Male
Nordihydroguaiaretic Acid / pharmacology
Platelet Activating Factor / antagonists & inhibitors*
Platelet Aggregation Inhibitors / pharmacology*
Theophylline / pharmacology
Thromboxane B2 / blood
Triazoles / pharmacology
Umbelliferones / pharmacology
Vasoconstriction / drug effects*
Vasoconstrictor Agents / pharmacology
Chemical
Reg. No./Substance:
0/Azepines; 0/Bronchoconstrictor Agents; 0/Diterpenes; 0/Endothelins; 0/Ginkgolides; 0/Lactones; 0/Lipoxygenase Inhibitors; 0/Platelet Activating Factor; 0/Platelet Aggregation Inhibitors; 0/Triazoles; 0/Umbelliferones; 0/Vasoconstrictor Agents; 114776-28-2/bepafant; 305-01-1/esculetin; 317-34-0/Aminophylline; 34580-13-7/Ketotifen; 500-38-9/Nordihydroguaiaretic Acid; 54397-85-2/Thromboxane B2; 58-55-9/Theophylline; 99796-69-7/ginkgolide B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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