| Influence of ambient temperature on peripherally induced interleukin-1 beta fever in young and old rats. | |
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MedLine Citation:
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PMID: 16762379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have previously demonstrated that old and young rats mount similar fevers after intraperitoneal (i.p.) LPS injection at a warm ambient temperature (Ta) of 31 degrees C, but not at a cooler Ta of 21 degrees C. LPS stimulates the synthesis and release of proinflammatory cytokines, particularly interleukin-1 beta (IL-1 beta), necessary for fever development, and possibly this is attenuated at the lower Ta. If so, then administration of exogenous IL-1 beta should enable old rats to mount fevers equivalent to those of young rats regardless of Ta. Here, young (3-5 months) and old (23-29 months) Long-Evans rats were maintained at Ta 21 or 31 degrees C for 3 days prior to i.p. or intravenous (i.v.) injection of rat recombinant IL-1 beta (1 microg/kg) or vehicle. Three days later, rats were given the alternate injection at the same T(a). At least 5 days later, the same rats were injected at the other Ta. Body temperature was continuously monitored throughout the experiments. Young rats mounted fevers after LPS at both Ta's and i.p. fevers were lower than i.v. fevers. Old rats developed fevers that were equivalent to those of young rats at 31 degrees C regardless of route of administration, but no fever responses were evident at 21 degrees C. These data suggest that the attenuated fever of old rats is not due to an inability to produce IL-1 beta, but rather to a deficiency further along in the fever pathway. In addition, these results show that, as with LPS, Ta plays a role in the ability of old rats to mount fever in response to IL-1 beta. |
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Authors:
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Jessica B Buchanan; Elizabeth Peloso; Evelyn Satinoff |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-06-09 |
Journal Detail:
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Title: Physiology & behavior Volume: 88 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-31 Completed Date: 2006-09-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 453-8 Citation Subset: IM |
Affiliation:
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Department of Psychology and Program in Neuroscience, University of Delaware, Newark, Delaware 19716-2590, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Female Fever / chemically induced*, physiopathology* Injections, Intraperitoneal Injections, Intravenous Interleukin-1* Male Rats Rats, Long-Evans Recombinant Proteins / pharmacology Temperature |
| Grant Support | |
ID/Acronym/Agency:
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R01-MH41138/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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