Document Detail


Influence of aluminium on neurotoxicity of lead in adult male albino rats.
MedLine Citation:
PMID:  15266904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Influence of aluminium on neurotoxicity of lead was studied in male albino rats. Aluminium enhanced the net deposition of lead in brain. This was further substantiated by higher levels of malondialdehyde (MDA), and lower activities of acetylcholinesterase enzyme in the brain homogenates of the rats treated with both lead and aluminium as compared to those of rats treated with lead only. In lead plus aluminium treated animals, a significant neurological deficit was observed when the animals were subjected to rota-rod, traction performance (TP) and tail immersion tests.
Authors:
A Shakoor; P K Gupta; M Kataria
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  41     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2004-07-22     Completed Date:  2004-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  587-91     Citation Subset:  IM    
Affiliation:
Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar 243 122, India.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / metabolism
Aluminum / toxicity*
Animals
Brain Stem / drug effects*,  enzymology
Male
Malondialdehyde / metabolism
Rats
Reaction Time
Chemical
Reg. No./Substance:
542-78-9/Malondialdehyde; 7429-90-5/Aluminum; EC 3.1.1.7/Acetylcholinesterase

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