Document Detail

Influence of alpha 1-adrenoceptor blockade and/or 5-HT1A agonism on blood pressure and heart rate at rest and during exercise in hypertensive dogs.
MedLine Citation:
PMID:  1352778     Owner:  NLM     Status:  MEDLINE    
1. Antihypertensive effects resulting from alpha 1-adrenoceptor blockade and stimulation of central nervous 5-HT1A receptors were compared with the effects arising from stimulation of 5-HT1A receptors alone during arterial hypertension. 2. Urapidil and 5-methyl-urapidil were less effective in decreasing arterial blood pressure than the lowest dose of the selective 5-HT1A receptor agonist, flesinoxan. After the higher dose of urapidil, a certain dampening of barareceptor reflex was found which was also seen with flesinoxan. 3. Flesinoxan was the only drug which did not reduce the exercise-induced increase in systolic arterial blood pressure. 4. Stimulation of 5-HT1A receptors alone, which is assumed to occur with flesinoxan, exerted antihypertensive activity only at low doses, without inducing reflex tachycardia at rest. 5. Only the combined effects of alpha 1-adrenoceptor blockade and 5-HT1A receptor stimulation, as assumed to occur with urapidil and 5-methyl-urapidil, lead to both a decrease in arterial blood pressure at rest and during exercise.
J G Grohs; S Huber; G Fischer; G Raberger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of autonomic pharmacology     Volume:  12     ISSN:  0144-1795     ISO Abbreviation:  J Auton Pharmacol     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-08-14     Completed Date:  1992-08-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8106455     Medline TA:  J Auton Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  IM    
Department of Cardiovascular Pharmacology, University of Vienna, Austria.
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology*
Blood Pressure / drug effects*
Heart Rate / drug effects*
Hypertension / physiopathology*
Physical Exertion / physiology*
Receptors, Serotonin / drug effects*
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Receptors, Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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