Document Detail


Influence of alcohol on early Glasgow Coma Scale in head-injured patients.
MedLine Citation:
PMID:  21068620     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To assess the depressant effects of alcohol on the level of consciousness of patients admitted with head injuries, this study examined the changes that occur in the Glasgow Coma Scale (GCS) of traumatic brain injury patients over time.
METHODS: The records of 269 head trauma patients consecutively admitted to the neurosurgery intensive care unit were examined retrospectively. Eighty-one patients were excluded because of incomplete data. The remaining 188 patients were further divided into an intoxicated group (blood alcohol concentration [BAC] ≥ 0.08%, n = 100 [53%]) and a nonintoxicated group (BAC <0.08%, n = 88 [47%]). The GCS in the prehospital setting, in the emergency department, and the highest GCS achieved during the first 24 hours postinjury were compared.
RESULTS: The change between emergency department-GCS and the best day 1 GCS in the intoxicated group was greater than the nonintoxicated group and deemed clinically and statistically significant; median change (3 vs. 0) p < 0.001. To assess whether these results were directly related to the BAC%, piecewise regression using a general linear model was used to assess the intercept and slope of alcohol on the changes of GCS with cutting point at BAC% = 0.08. The analysis showed that, in the nonintoxicated range, the effect of alcohol was not significantly related to the changes of GCS. But in the intoxicated range, BAC% was significantly positively related to the changes of GCS.
CONCLUSION: This study concludes that the GCS increases significantly over time in alcohol intoxicated patients with traumatic brain injury.
Authors:
Hazem Shahin; Shankar P Gopinath; Claudia S Robertson
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of trauma     Volume:  69     ISSN:  1529-8809     ISO Abbreviation:  J Trauma     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-11     Completed Date:  2011-01-11     Revised Date:  2014-01-22    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1176-81; discussion 1181     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcoholic Intoxication / complications,  diagnosis,  physiopathology*
Consciousness / physiology*
Craniocerebral Trauma / complications,  diagnosis*,  physiopathology
Female
Follow-Up Studies
Glasgow Coma Scale / trends*
Humans
Male
Middle Aged
Prognosis
Retrospective Studies
Trauma Centers
Young Adult
Grant Support
ID/Acronym/Agency:
P01 NS038660/NS/NINDS NIH HHS; P01 NS038660-10S1/NS/NINDS NIH HHS; P01-NS38660/NS/NINDS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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