| Influence of alcohol on early Glasgow Coma Scale in head-injured patients. | |
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MedLine Citation:
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PMID: 21068620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To assess the depressant effects of alcohol on the level of consciousness of patients admitted with head injuries, this study examined the changes that occur in the Glasgow Coma Scale (GCS) of traumatic brain injury patients over time. METHODS: The records of 269 head trauma patients consecutively admitted to the neurosurgery intensive care unit were examined retrospectively. Eighty-one patients were excluded because of incomplete data. The remaining 188 patients were further divided into an intoxicated group (blood alcohol concentration [BAC] ≥ 0.08%, n = 100 [53%]) and a nonintoxicated group (BAC <0.08%, n = 88 [47%]). The GCS in the prehospital setting, in the emergency department, and the highest GCS achieved during the first 24 hours postinjury were compared. RESULTS: The change between emergency department-GCS and the best day 1 GCS in the intoxicated group was greater than the nonintoxicated group and deemed clinically and statistically significant; median change (3 vs. 0) p < 0.001. To assess whether these results were directly related to the BAC%, piecewise regression using a general linear model was used to assess the intercept and slope of alcohol on the changes of GCS with cutting point at BAC% = 0.08. The analysis showed that, in the nonintoxicated range, the effect of alcohol was not significantly related to the changes of GCS. But in the intoxicated range, BAC% was significantly positively related to the changes of GCS. CONCLUSION: This study concludes that the GCS increases significantly over time in alcohol intoxicated patients with traumatic brain injury. |
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Authors:
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Hazem Shahin; Shankar P Gopinath; Claudia S Robertson |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of trauma Volume: 69 ISSN: 1529-8809 ISO Abbreviation: J Trauma Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-11 Completed Date: 2011-01-11 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: United States |
Other Details:
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Languages: eng Pagination: 1176-81; discussion 1181 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, USA. shahinhazem@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcoholic Intoxication / complications, diagnosis, physiopathology* Consciousness / physiology* Craniocerebral Trauma / complications, diagnosis*, physiopathology Female Follow-Up Studies Glasgow Coma Scale / trends* Humans Male Middle Aged Prognosis Retrospective Studies Trauma Centers Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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P01 NS038660-10S1/NS/NINDS NIH HHS; P01-NS38660/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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