Document Detail


Influence of age on syncope following prolonged exercise: differential responses but similar orthostatic intolerance.
MedLine Citation:
PMID:  19884316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Orthostatic tolerance is reduced with increasing age and following prolonged exercise. The aim of this study was to determine the effect of age on cardiovascular and cerebrovascular responses to orthostatic stress following prolonged exercise. Measurements were obtained before, and within 45 min after, 4 h of continuous running at 70-80% of maximal heart rate in nine young (Y; 27 +/- 4 years; V(O(2)max)) 59 +/- 10 ml kg(1) min(1)) and twelve older (O; 65 +/- 5 years; V(O(2)max)) 46 +/- 8 ml kg(1) min(1)) athletes. Middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound), blood pressure (BP; Finometer) and stroke volume (SV) were measured continuously whilst supine and during 60 deg head-up tilt for 15 min or to pre-syncope. Orthostatic tolerance was reduced post-exercise (tilt completed (min:s, mean +/- s.d.): Pre, 14:39 +/- 0:55; Post, 5:59 +/- 4:53; P < 0.05), but did not differ with age (P > 0.05). Despite a 25% higher supine MCAv in the young, MCAv at syncope was the same in both groups (Y: 34 +/- 10 cm s(1); O: 32 +/- 13; P > 0.05). Although the hypotensive response to syncope did not differ with age, the components of BP did; SV was lowered more in the young (Y: -57 +/- 16%; O: -34 +/- 13%; P < 0.05); and total peripheral resistance was lowered in the older athletes but was unchanged in the young (Y: +8 +/- 10%; O: -21 +/- 12%; (at 10 s pre-syncope) P < 0.05). Despite a lower MCAv in the older athletes, time to syncope was similar between groups; however, the integrative mechanisms responsible for syncope did differ with age. The similar MCAv at pre-syncope indicates there is an age-independent critical cerebral blood flow threshold at which syncope occurs.
Authors:
Carissa Murrell; James D Cotter; Keith George; Robert Shave; Luke Wilson; Kate Thomas; Michael J A Williams; Tim Lowe; Philip N Ainslie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of physiology     Volume:  587     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-02-26     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  5959-69     Citation Subset:  IM    
Affiliation:
Department of Human Kinetics, University of British Columbia-Okanagan, Kelowna, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aging*
Exercise Tolerance*
Female
Humans
Male
Orthostatic Intolerance / physiopathology*
Physical Endurance*
Physical Exertion*
Syncope / physiopathology*
Young Adult
Comments/Corrections
Comment In:
J Physiol. 2010 Jan 1;588(Pt 1):19   [PMID:  20045902 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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