Document Detail

Influence of age on the signal transduction of T cells in mice.
MedLine Citation:
PMID:  8241056     Owner:  NLM     Status:  MEDLINE    
A 5- to 10-fold decline was observed in the proliferative activity of T cells stimulated with anti-CD3 mAb between young and old mice. However, the number of CD3 molecules on the T cell surface was almost comparable between young and old T cells. The formation of the second messenger such as inositol triphosphate (IP3) and diacylglycerol (DAG) after mitogenic stimulation decreased in old T cells as compared with young ones. The activity of phospholipase C (PLC), which is responsible for the liberation of IP3 and DAG from phosphatidylinositol-4,5-bisphosphate (PIP2) was not different between young and old T cells. The content of PIP2 in the membrane was also comparable between young and old T cells. These findings have suggested that the age-related decline in the proliferative activity of T cells could be due to impairment of intracellular signal transduction, probably in the pathway somewhere between TCR and PLC.
M Utsuyama; Z Varga; K Fukami; Y Homma; T Takenawa; K Hirokawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International immunology     Volume:  5     ISSN:  0953-8178     ISO Abbreviation:  Int. Immunol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-01-06     Completed Date:  1994-01-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8916182     Medline TA:  Int Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1177-82     Citation Subset:  IM    
Department of Pathology, Tokyo Metropolitan Institute of Gerontology, Japan.
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MeSH Terms
Aging / physiology*
Antigens, CD3 / metabolism
Diglycerides / metabolism
Flow Cytometry
Inositol 1,4,5-Trisphosphate / metabolism
Lymphocyte Activation
Mice, Inbred C57BL
Phosphatidylinositol 4,5-Diphosphate
Phosphatidylinositol Phosphates / metabolism
Signal Transduction / physiology*
T-Lymphocytes / immunology,  metabolism*
Type C Phospholipases / metabolism
Reg. No./Substance:
0/Antigens, CD3; 0/Diglycerides; 0/Phosphatidylinositol 4,5-Diphosphate; 0/Phosphatidylinositol Phosphates; 85166-31-0/Inositol 1,4,5-Trisphosphate; EC 3.1.4.-/Type C Phospholipases

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