| Influence of age on the signal transduction of T cells in mice. | |
| | |
MedLine Citation:
|
PMID: 8241056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A 5- to 10-fold decline was observed in the proliferative activity of T cells stimulated with anti-CD3 mAb between young and old mice. However, the number of CD3 molecules on the T cell surface was almost comparable between young and old T cells. The formation of the second messenger such as inositol triphosphate (IP3) and diacylglycerol (DAG) after mitogenic stimulation decreased in old T cells as compared with young ones. The activity of phospholipase C (PLC), which is responsible for the liberation of IP3 and DAG from phosphatidylinositol-4,5-bisphosphate (PIP2) was not different between young and old T cells. The content of PIP2 in the membrane was also comparable between young and old T cells. These findings have suggested that the age-related decline in the proliferative activity of T cells could be due to impairment of intracellular signal transduction, probably in the pathway somewhere between TCR and PLC. |
| | |
Authors:
|
M Utsuyama; Z Varga; K Fukami; Y Homma; T Takenawa; K Hirokawa |
Related Documents
:
|
15489886 - Molecular signature of oncogenic ras-induced senescence. 16055186 - Evaluation of manisa propolis effect on leukemia cell line by telomerase activity. 4880406 - The parathyroid oxyphil cells. 9012586 - Genetic, epigenetic, dysgenetic, and non-genetic mechanisms in tumorigenesis. 8666236 - Caulobacter lon protease has a critical role in cell-cycle control of dna methylation. 15570596 - Cell proliferation dynamics and morphological differentiation during regeneration in do... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International immunology Volume: 5 ISSN: 0953-8178 ISO Abbreviation: Int. Immunol. Publication Date: 1993 Sep |
Date Detail:
|
Created Date: 1994-01-06 Completed Date: 1994-01-06 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8916182 Medline TA: Int Immunol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1177-82 Citation Subset: IM |
Affiliation:
|
Department of Pathology, Tokyo Metropolitan Institute of Gerontology, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
physiology* Animals Antigens, CD3 / metabolism Diglycerides / metabolism Flow Cytometry Inositol 1,4,5-Trisphosphate / metabolism Lymphocyte Activation Male Mice Mice, Inbred C57BL Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositol Phosphates / metabolism Signal Transduction / physiology* T-Lymphocytes / immunology, metabolism* Type C Phospholipases / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD3; 0/Diglycerides; 0/Phosphatidylinositol 4,5-Diphosphate; 0/Phosphatidylinositol Phosphates; 85166-31-0/Inositol 1,4,5-Trisphosphate; EC 3.1.4.-/Type C Phospholipases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of conserved regions of class I MHC molecules in the activation of CD8+ cytotoxic T lymphocytes...
Next Document: IL-5 receptor positive B cells, but not eosinophils, are functionally and numerically influenced in ...