Document Detail

Influence of age-related changes in nitric oxide synthase-expressing neurons in the rat supraoptic nucleus on inhibition of salivary secretion.
MedLine Citation:
PMID:  18464528     Owner:  NLM     Status:  MEDLINE    
Age-related inhibition of salivary secretion has been demonstrated in rats, and the nitric oxide (NO) present in the supraoptic nucleus (SON) and the medial septal area has been reported to play an inhibitory role in the regulation of salivary secretion. In the present study, we investigated the age-related changes occurring in the NO synthase (NOS)-expressing neurons in the SON, which is related to the production of NO, and discussed the interrelation between the age-related changes in the NOS-expressing neurons and the age-related inhibition of salivary secretion. Nissl staining and reduced nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) histochemistry were performed for young adult and aged rats. Quantitative analysis was also performed using the Nissl-stained and NADPH-d-positive neurons. Although the numbers of the Nissl-stained neurons did not change, significant age-related increases were detected in cell number, cell size and reactive density of the NADPH-d-positive neurons. Therefore, the production of NO in the SON neurons increased with age. We concluded that the age-related increase in the NO in the SON might be a factor that contributes to the age-related inhibition of salivary secretion.
Takehiko Tanaka; Yoshitaka Tamada; Fumihiko Suwa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Okajimas folia anatomica Japonica     Volume:  84     ISSN:  0030-154X     ISO Abbreviation:  Okajimas Folia Anat Jpn     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-06-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401014     Medline TA:  Okajimas Folia Anat Jpn     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  125-31     Citation Subset:  IM    
Department of Anatomy, Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata-shi, Osaka 573-1121, Japan.
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MeSH Terms
Aging / physiology*
Autonomic Pathways / cytology,  enzymology*
Brain Stem / enzymology
Cell Count
Cell Proliferation
Cell Size
Image Cytometry
NADPH Dehydrogenase / analysis,  biosynthesis
Neural Inhibition / physiology
Nitrergic Neurons / cytology,  enzymology*
Nitric Oxide / analysis,  biosynthesis
Nitric Oxide Synthase Type I / metabolism*
Rats, Sprague-Dawley
Saliva / secretion
Salivation / physiology*
Staining and Labeling
Supraoptic Nucleus / cytology,  enzymology*
Reg. No./Substance:
10102-43-9/Nitric Oxide; EC Oxide Synthase Type I; EC Dehydrogenase

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