| Influence of age-related changes in nitric oxide synthase-expressing neurons in the rat supraoptic nucleus on inhibition of salivary secretion. | |
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MedLine Citation:
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PMID: 18464528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Age-related inhibition of salivary secretion has been demonstrated in rats, and the nitric oxide (NO) present in the supraoptic nucleus (SON) and the medial septal area has been reported to play an inhibitory role in the regulation of salivary secretion. In the present study, we investigated the age-related changes occurring in the NO synthase (NOS)-expressing neurons in the SON, which is related to the production of NO, and discussed the interrelation between the age-related changes in the NOS-expressing neurons and the age-related inhibition of salivary secretion. Nissl staining and reduced nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) histochemistry were performed for young adult and aged rats. Quantitative analysis was also performed using the Nissl-stained and NADPH-d-positive neurons. Although the numbers of the Nissl-stained neurons did not change, significant age-related increases were detected in cell number, cell size and reactive density of the NADPH-d-positive neurons. Therefore, the production of NO in the SON neurons increased with age. We concluded that the age-related increase in the NO in the SON might be a factor that contributes to the age-related inhibition of salivary secretion. |
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Authors:
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Takehiko Tanaka; Yoshitaka Tamada; Fumihiko Suwa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Okajimas folia anatomica Japonica Volume: 84 ISSN: 0030-154X ISO Abbreviation: Okajimas Folia Anat Jpn Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-05-09 Completed Date: 2008-06-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401014 Medline TA: Okajimas Folia Anat Jpn Country: Japan |
Other Details:
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Languages: eng Pagination: 125-31 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata-shi, Osaka 573-1121, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Autonomic Pathways / cytology, enzymology* Brain Stem / enzymology Cell Count Cell Proliferation Cell Size Histocytochemistry Image Cytometry Male NADPH Dehydrogenase / analysis, biosynthesis Neural Inhibition / physiology Nitrergic Neurons / cytology, enzymology* Nitric Oxide / analysis, biosynthesis Nitric Oxide Synthase Type I / metabolism* Rats Rats, Sprague-Dawley Saliva / secretion Salivation / physiology* Staining and Labeling Supraoptic Nucleus / cytology, enzymology* |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; EC 1.14.13.39/Nitric Oxide Synthase Type I; EC 1.6.99.1/NADPH Dehydrogenase |
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