| Influence of age on noise- and styrene-induced hearing loss in the Long-Evans rat. | |
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MedLine Citation:
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PMID: 21783527 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This paper reviews different investigations carried out with Long-Evans rats on the influence of age on the ototoxicity induced by styrene and on the vulnerability to noise. The first part of this article is focused on the differences in auditory susceptibility to noise (92 or 97dB octave band noise centered at 8kHz, 6 h/day, 5 days/week, 4 weeks) and styrene (700ppm, 6h/d, 5 d/w, 4 w) between young (three and half months) and old (24 months) Long-Evans rats. Auditory evoked potential measures revealed that the old rats tend to be more sensitive than young rats to higher noise levels (97dB), but equally vulnerable to moderate levels (92dB). By contrast, the aged rats were virtually insensitive to 700ppm styrene compared to the young animals. Two additional studies were performed controlling and examining the influence of body weight and post-natal age on the sensitivity to styrene. Rats of the same age (21 weeks) and but having different body weight (∼310g versus ∼410g) did not show any difference of sensitivity to 700ppm styrene, whereas 14-week-old rats with the same body weight as 21-week-old rats (∼350g) revealed increased sensitivity to styrene. These results show that weight does not play a key role in the sensitivity to styrene, and suggest a long period of increased sensitivity to styrene during the first months of life. |
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Authors:
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Benoît Pouyatos; Pierre Campo; Robert Lataye |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Environmental toxicology and pharmacology Volume: 19 ISSN: 1382-6689 ISO Abbreviation: Environ. Toxicol. Pharmacol. Publication Date: 2005 May |
Date Detail:
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Created Date: 2011-07-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612020 Medline TA: Environ Toxicol Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 561-70 Citation Subset: - |
Affiliation:
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Institut National de Recherche et de Sécurité, Ave de Bourgogne, BP 27, 54501 Vandoeuvre, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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