Document Detail

Influence of age on left ventricular performance during exercise in normal Japanese subject: assessment by radionuclide ventriculography.
MedLine Citation:
PMID:  2206768     Owner:  NLM     Status:  MEDLINE    
To assess the effects of age on left ventricular performance, multistage supine ergometer exercise radionuclide ventriculography (RNV) was performed in 92 normal subjects. The subjects ranged in age from 24 to 86 years and were free of cardiopulmonary disease and diabetes. Age-related changes in exercise duration, left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), cardiac output (CO) left ventricular ejection fraction (LVEF), left ventricular dv/dt, systolic and diastolic time indexes of dv/dt, and peak systolic pressure/left ventricular end-systolic volume (PSP/LVESV) were analyzed at rest and during the peak exercise stage. Age-related decrease in LVEDV and peak diastolic dv/dt were significant at rest. The time indexes of ECG R to peak systolic dv/dt and time of end-systole to peak diastolic dv/dt also were prolonged with age. Both maximum heart rate and exercise duration were shown to decline with age. No age-related difference was observed in LVESV, LVEF or PSP/LVESV either at rest or during exercise. However, the change of LVEF and LVESV during exercise was less in subjects aged 60 or more. These results indicate decreased left ventricular function during exercise in elderly subjects.
T Konishi; T Koyama; T Aoki; K Makino; M Yamamuro; K Nakai; M Nakamura; T Nakano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  4     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-11-13     Completed Date:  1990-11-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  19-27     Citation Subset:  IM    
First Department of Internal Medicine, Mie University School of Medicine, Japan.
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MeSH Terms
Aged, 80 and over
Aging / physiology*
Gated Blood-Pool Imaging*
Middle Aged
Physical Exertion / physiology*
Reference Values
Ventricular Function, Left / physiology*

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