Document Detail

Influence of age, hyperglycemia, leptin, and NPY on islet blood flow in obese-hyperglycemic mice.
MedLine Citation:
PMID:  9755077     Owner:  NLM     Status:  MEDLINE    
This study aimed to elucidate possible age-related changes in islet blood perfusion in lean and obese C57BL/6 mice. Obese mice aged 1 mo were hyperglycemic and hyperinsulinemic and had an increased islet blood flow compared with age-matched lean mice. This augmented blood flow could be abolished by pretreatment with leptin. The islet blood perfusion was, in contrast to this, markedly decreased in obese 6- to 7-mo-old animals compared with age-matched lean mice. Reversal of hyperglycemia, but not hyperinsulinemia, in these obese mice with phlorizin normalized the islet blood flow. Spontaneous reversal of hyperglycemia, but not hyperinsulinemia, was seen in the 12-mo-old obese mice. Islet blood perfusion in obese mice at this age did not differ compared with lean mice. It is suggested that the initial increase in islet blood flow in obese mice is due to the leptin deficiency. The subsequent decrease in islet blood perfusion is probably caused by the chronic hyperglycemia. The described islet blood flow changes may be of importance for impairment of islet function in obese-hyperglycemic mice.
P O Carlsson; A Andersson; L Jansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  275     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-11-23     Completed Date:  1998-11-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E594-601     Citation Subset:  IM    
Department of Medical Cell Biology, Uppsala University, S-75123 Uppsala, Sweden.
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MeSH Terms
Aging / physiology*
Arginine / analogs & derivatives*,  pharmacology
Blood Glucose / metabolism
Body Weight
Hyperglycemia / genetics,  physiopathology*
Hyperinsulinism / physiopathology
Insulin / blood,  secretion*
Islets of Langerhans / blood supply*,  drug effects,  growth & development
Mice, Inbred C57BL
Mice, Obese
Neuropeptide Y / physiology
Obesity / genetics,  physiopathology*
Organ Size
Pancreas / anatomy & histology*,  drug effects,  growth & development
Phlorhizin / pharmacology*
Proteins / pharmacology*
Receptors, Leptin
Receptors, Neuropeptide Y / antagonists & inhibitors,  physiology*
Regional Blood Flow / drug effects
Reg. No./Substance:
0/BIBP 3226; 0/Blood Glucose; 0/Leptin; 0/Neuropeptide Y; 0/Proteins; 0/Receptors, Leptin; 0/Receptors, Neuropeptide Y; 0/leptin receptor, mouse; 11061-68-0/Insulin; 60-81-1/Phlorhizin; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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