| Influence of age and co-medication on steady-state carbamazepine serum level-dose ratios in Japanese paediatric patients. | |
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MedLine Citation:
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PMID: 1548316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of age and co-medication on steady-state carbamazepine (CBZ) level-dose (L/D) ratios were evaluated retrospectively in 370 paediatric patients. The CBZ L/D ratio increased significantly with age up to 15 years in patients on monotherapy (L/D = 0.051 x AGE + 0.334, n = 111, r = 0.593, P less than 0.001). Associated anti-epileptic therapy affected the CBZ L/D ratio, which was significantly reduced in patients on polytherapy as compared to patients on monotherapy. The study therefore suggests that routine monitoring of CBZ serum levels is extremely useful, especially in the paediatric age group, and in patients who require associated anti-epileptic medication. |
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Authors:
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E Yukawa; A Suzuki; S Higuchi; T Aoyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pharmacy and therapeutics Volume: 17 ISSN: 0269-4727 ISO Abbreviation: J Clin Pharm Ther Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-04-17 Completed Date: 1992-04-17 Revised Date: 2008-05-28 |
Medline Journal Info:
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Nlm Unique ID: 8704308 Medline TA: J Clin Pharm Ther Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 65-9 Citation Subset: IM |
Affiliation:
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Department of Hospital Pharmacy, Kyushu University Hospital, Faculty of Medicine, Fukuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Factors Algorithms Asian Continental Ancestry Group Carbamazepine / administration & dosage, blood* Child Child, Preschool Drug Therapy, Combination Female Humans Infant Infant, Newborn Japan Male |
| Chemical | |
Reg. No./Substance:
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298-46-4/Carbamazepine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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