Document Detail


Influence of age on arterial baroreflex inhibition of sympathetic nerve activity in healthy adult humans.
MedLine Citation:
PMID:  9815084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Resting levels of muscle sympathetic nerve activity (MSNA) increase markedly with age in healthy adult humans. An age-related reduction in arterial baroreflex inhibition of MSNA could contribute to these elevations. To test this hypothesis, we measured MSNA using peroneal microneurography in young (age, 25 +/- 1 yr; n = 8) and older (69 +/- 1 yr; n = 7) healthy normotensive men before (baseline control) and during graded constant infusion of phenylephrine hydrochloride (0.5-2.0 microgram . kg-1. min-1) that produced a sustained approximately 10-mmHg increase in arterial blood pressure. Central venous pressure was controlled at baseline levels (+/-1 mmHg) using lower body negative pressure. Resting MSNA was approximately 95% higher in the older compared with the young subjects (43 +/- 5 vs. 22 +/- 3 bursts/min; P < 0.05). However, arterial baroreflex MSNA inhibitory responsiveness was similar in the older compared with the young subjects (254 +/- 112 vs. 259 +/- 40 arbitrary integration units/mmHg, respectively), although the percent reduction in MSNA was smaller in the older men (8.9 +/- 0.7 vs. 5.2 +/- 1.1%/mmHg), due to their elevated baseline levels. The reflex increase in the R-R interval was not different in the two groups (13 +/- 10 vs. 16 +/- 7 ms/mmHg). In summary, our findings suggest that arterial baroreflex inhibition of MSNA is preserved with age in healthy normotensive adult humans. As such, this mechanism does not appear to contribute to the age-related rise in tonic MSNA.
Authors:
K P Davy; H Tanaka; E A Andros; J G Gerber; D R Seals
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  275     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-12-10     Completed Date:  1998-12-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1768-72     Citation Subset:  IM    
Affiliation:
Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, Colorado 80309, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aging / physiology*
Arteries / innervation*,  physiology*
Baroreflex / physiology*
Heart Rate / physiology
Humans
Male
Middle Aged
Sympathetic Nervous System / physiology*
Grant Support
ID/Acronym/Agency:
AG-06537/AG/NIA NIH HHS; AG-13038/AG/NIA NIH HHS; HL-39966/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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