Document Detail

Influence of age on BDNF modulation of hippocampal synaptic transmission: interplay with adenosine A2A receptors.
MedLine Citation:
PMID:  17421024     Owner:  NLM     Status:  MEDLINE    
We previously reported that adenosine, through A(2A) receptor activation, potentiates synaptic actions of brain-derived neurotrophic factor (BDNF) in the hippocampus of infant (3-4 weeks) rats. Since A(2A)-receptor-mediated actions are more evident in old than in young rats and since the therapeutic potential for BDNF-based strategies is greater in old subjects, we now evaluated synaptic actions of BDNF and the levels of TrkB receptors and of adenosine A(2A) receptors in the hippocampus of three groups of adult rats: young adults (10-16 weeks), old adults (36-38 weeks), and aged (70-80 weeks), as well as in one group of infant (3-4 weeks) rats. BDNF (20 ng/ml) enhances field excitatory postsynaptic potentials recorded from the hippocampus of young adults and aged rats, an action triggered by adenosine A(2A) receptor activation, since it was blocked by the A(2A) receptor antagonist, ZM 241385. In the other groups of animals BDNF (20 ng/ml) was virtually devoid of action on synaptic transmission. Western blot analysis of receptor density shows decreased amounts of TrkB receptors in old adults and aged rats, whereas A(2A) receptor levels assayed by ligand binding are enhanced in the hippocampus of old adults and aged rats. It is concluded that age-related changes in the density of TrkB receptors and of adenosine A(2A) receptors may be responsible for a nonmonotonous variation of BDNF actions on synaptic transmission in the hippocampus.
Maria J Diógenes; Natália Assaife-Lopes; António Pinto-Duarte; Joaquim A Ribeiro; Ana M Sebastião
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hippocampus     Volume:  17     ISSN:  1050-9631     ISO Abbreviation:  Hippocampus     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-09-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9108167     Medline TA:  Hippocampus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  577-85     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
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MeSH Terms
Adenosine / metabolism
Aging / physiology*
Binding, Competitive / physiology
Brain-Derived Neurotrophic Factor / metabolism*,  pharmacology
Down-Regulation / drug effects,  physiology
Excitatory Postsynaptic Potentials / drug effects,  physiology
Hippocampus / drug effects,  growth & development*,  metabolism*
Neural Pathways / drug effects,  growth & development,  metabolism
Organ Culture Techniques
Presynaptic Terminals / metabolism
Radioligand Assay
Rats, Wistar
Receptor, Adenosine A2A / agonists,  metabolism*
Receptor, trkB / agonists,  metabolism
Synaptic Transmission / drug effects,  physiology*
Up-Regulation / drug effects,  physiology
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Receptor, Adenosine A2A; 58-61-7/Adenosine; EC, trkB

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