| Influence of adrenaline on blood perfusion and vascular conductance of the whole pancreas and the islets of Langerhans in the rat. | |
| | |
MedLine Citation:
|
PMID: 1816767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The blood perfusion and vascular conductance of the whole pancreas and of the islet organ were measured separately with the aid of a microsphere technique after intravenous infusion (0.1 ml/min) of adrenaline in different doses (1, 2 or 3 micrograms/kg body weight x min). Control animals were infused with saline alone and had a mean arterial blood pressure of approximately 100 mm Hg. Adrenaline increased the mean arterial blood pressure to 150, 175 and 200 mm Hg, respectively. A decrease of both whole pancreatic blood flow and islet blood flow could be seen after adrenaline administration, but no differences were observed between the two highest doses (greater than 2 micrograms/kg body weight x min of adrenaline). The fraction of blood diverted through the islets was approximately 10% of the whole pancreatic blood flow in all experimental groups. Also the vascular conductance decreased more than the blood perfusion values. It is concluded that adrenaline produces a decrease of blood flow to both the islets and the whole pancreas, which is similar in both the endocrine and exocrine tissue. |
| | |
Authors:
|
L Jansson |
Related Documents
:
|
6357137 - Microcirculation of the pancreas: a correlative study of intravital microscopy with sca... 9220427 - Blood flow patterns in the rat pancreas: a simulative demonstration by injection replic... 3814497 - The functioning in unanaesthetized sheep of the popliteal lymph node after the surgical... 15298987 - Effect of pancreatic and leukocyte elastase on hydraulic conductivity in lung interstit... 1015927 - Effect of furosemide on renal hilar lymph flow. 2188697 - Is intrauterine growth retardation with normal umbilical artery blood flow a benign con... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Archives internationales de pharmacodynamie et de thérapie Volume: 313 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1991 Sep-Oct |
Date Detail:
|
Created Date: 1992-06-29 Completed Date: 1992-06-29 Revised Date: 2012-01-12 |
Medline Journal Info:
|
Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
|
Languages: eng Pagination: 90-7 Citation Subset: IM |
Affiliation:
|
Department of Medical Cell Biology, Uppsala University, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Blood Pressure / drug effects Epinephrine / pharmacology* Islets of Langerhans / blood supply, drug effects* Male Pancreas / blood supply, drug effects* Rats Rats, Inbred Strains Regional Blood Flow / drug effects |
| Chemical | |
Reg. No./Substance:
|
51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Digitalis glycosides accentuate the depressant effect of anoxia and reoxygenation on the cardiac myo...
Next Document: Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin [corrected]