Document Detail

Influence of adrenaline on blood perfusion and vascular conductance of the whole pancreas and the islets of Langerhans in the rat.
MedLine Citation:
PMID:  1816767     Owner:  NLM     Status:  MEDLINE    
The blood perfusion and vascular conductance of the whole pancreas and of the islet organ were measured separately with the aid of a microsphere technique after intravenous infusion (0.1 ml/min) of adrenaline in different doses (1, 2 or 3 micrograms/kg body weight x min). Control animals were infused with saline alone and had a mean arterial blood pressure of approximately 100 mm Hg. Adrenaline increased the mean arterial blood pressure to 150, 175 and 200 mm Hg, respectively. A decrease of both whole pancreatic blood flow and islet blood flow could be seen after adrenaline administration, but no differences were observed between the two highest doses (greater than 2 micrograms/kg body weight x min of adrenaline). The fraction of blood diverted through the islets was approximately 10% of the whole pancreatic blood flow in all experimental groups. Also the vascular conductance decreased more than the blood perfusion values. It is concluded that adrenaline produces a decrease of blood flow to both the islets and the whole pancreas, which is similar in both the endocrine and exocrine tissue.
L Jansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  313     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:    1991 Sep-Oct
Date Detail:
Created Date:  1992-06-29     Completed Date:  1992-06-29     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  90-7     Citation Subset:  IM    
Department of Medical Cell Biology, Uppsala University, Sweden.
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MeSH Terms
Analysis of Variance
Blood Pressure / drug effects
Epinephrine / pharmacology*
Islets of Langerhans / blood supply,  drug effects*
Pancreas / blood supply,  drug effects*
Rats, Inbred Strains
Regional Blood Flow / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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