Document Detail


Influence of admixed citric acid and physiological variables on the vinpocetine release from sodium alginate compressed matrix tablets.
MedLine Citation:
PMID:  21417613     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this study, the controlled release matrix tablets of vinpocetine were prepared by direct compression using sodium alginate (SAL) as hydrophilic polymer and different amounts of citric acid as hydrosoluble acidic excipient to set up a system bringing about zero-order release of this drug in distilled water containing 0.5% sodium dodecyl sulfate. At the critical content of admixed citric acid (60 mg/tab.), the lowest drug-release rate was observed. In order to explain the effect of this critical content on drug-release rate from SAL matrices, investigation of the possibility of interaction of citric acid with SAL was performed using differential scanning calorimetric analysis and infrared analysis, which confirmed the existence of direct citric acid-SAL interaction when these two excipients came in contact with water. A zero-order drug-release system could be obtained by regulating the ratio of citric acid-to-SAL and the capacity of this system in controlling drug-release rate depended on the extent of interaction between citric acid and SAL. It is worth noticing that pH and the ionic strength of the dissolution medium were found to exert an influence on the drug-release performance of SAL tablets.
Authors:
Shufang Nie; Jie Wu; Hui Liu; Weisan Pan; Yanli Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-21
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  -     ISSN:  1520-5762     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pharmaceutical Engineering, Wuhan Bioengineering Institute, Yangluo Economic Development Zone, Wuhan, China.
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