Document Detail

Influence of adenosine agonists and antiepileptic drugs on theophylline-induced seizures in rats.
MedLine Citation:
PMID:  10874349     Owner:  NLM     Status:  MEDLINE    
Seizures is a major toxicity of theophylline. The mechanism of theophylline-induced seizures is not known, but antagonism at adenosine receptors may be a possibility. The effect of pretreatment with different doses of adenosine (100, 500 and 1000 mg/kg, i.p.), and the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA), 1, 5 and 10 mg/kg, i.p., was studied against seizures induced by theophylline in rats. Both these drugs, at all dose levels tested, failed to protect theophylline seizures. Thus adenosinergic system is unlikely to be involved in mediating the convulsant action of theophylline. On the other hand, the conventional antiepileptic drugs, i.e. diazepam (4 mg/kg), sodium valproate (300 mg/kg) and phenobarbitone (50 mg/kg), but not carbamazepine, afforded some protection. The modification of course of seizures, by the antiepileptic drugs suggests the involvement of some other alternate mechanism in theophylline-induced seizures.
Y K Gupta; J Malhotra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  42     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  2000-07-19     Completed Date:  2000-07-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  491-7     Citation Subset:  IM    
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Adenosine / analogs & derivatives*,  therapeutic use*
Anti-Arrhythmia Agents / therapeutic use*
Anticonvulsants / therapeutic use
Phosphodiesterase Inhibitors / adverse effects
Rats, Wistar
Receptors, Purinergic P1 / agonists*
Seizures / chemically induced,  drug therapy*
Theophylline / adverse effects
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Anticonvulsants; 0/Phosphodiesterase Inhibitors; 0/Receptors, Purinergic P1; 41552-82-3/N(6)-cyclopentyladenosine; 58-55-9/Theophylline; 58-61-7/Adenosine

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