| Influence of acute and chronic treadmill exercise on rat plasma lactate and brain NPY, L-ENK, DYN A1-13. | |
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MedLine Citation:
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PMID: 16858636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to investigate the effect of acute and chronic high-intensity treadmill exercise on changes in plasma lactate and brain neuropeptide (NPY), leucine-enkephalin (L-ENK), and dynorphin A(1-13) (DYN A(1-13)). Avidin-biotin complex (ABC) immunohistochemistry and image pattern analysis were used to observe the effect of chronic (total 7 weeks) and acute treadmill exercise (an initial speed of 15 m min(-1) gradually increased to 35 m min(-1) with 0 degrees, 20-25 min per day duration) on the changes of NPY, L-ENK, and DYN A(1-13) in different areas of rat brain. Plasma lactate was also measured in response to such exercise. Compared with preexercise control (P < 0.01), plasma lactate concentration significantly increased in the immediate postexercise; but it returned to the normal level soon after the 30 min postexercise. The content of NPY in paraventricular (PVN), dorsomedial (DMN), and ventromedial (VMN) hypothalamic nuclei continued to increase in 0, 30, and 180 min postexercise compared with preexercise control (P < 0.01). The content of L-ENK in caudate-putamen (CPu) significantly increased in the immediate postexercise compared with preexercise control (P < 0.01), but it gradually returned to the normal level after the 180 min postexercise. However, the content of DYN A(1-13) in PVN rose substantially only in 30 min postexercise in comparison with the preexercise control (P < 0.01). Thus, different changes of NPY, L-ENK, and DYN A(1-13) in response to such high-intensity exercise depend on the brain region and the time examined, especially, the contents of NPY in different brain regions continuously remain at a high level after such high-intensity exercise. And this high level might reduce energy expenditure and thus contribute to the stimulation of brain NPY neurons. |
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Authors:
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Jia-Xu Chen; Xin Zhao; Guang-Xin Yue; Zhu-Feng Wang |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-07-21 |
Journal Detail:
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Title: Cellular and molecular neurobiology Volume: 27 ISSN: 0272-4340 ISO Abbreviation: Cell. Mol. Neurobiol. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-24 Completed Date: 2007-05-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200709 Medline TA: Cell Mol Neurobiol Country: United States |
Other Details:
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Languages: eng Pagination: 1-10 Citation Subset: IM |
Affiliation:
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Department of TCM Diagnosis, Beijing University of Traditional Chinese Medicine, No. 11, Beisanhuan Donglu, Chaoyang District, Beijing, 100029, People's Republic of China. chenjx@bjucmp.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Brain Chemistry* Dynorphins / analysis* Enkephalin, Leucine / analysis* Lactic Acid / blood* Male Neuropeptide Y / analysis* Peptide Fragments / analysis* Physical Conditioning, Animal* Rats Rats, Sprague-Dawley Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 0/Peptide Fragments; 50-21-5/Lactic Acid; 58822-25-6/Enkephalin, Leucine; 72957-38-1/dynorphin (1-13); 74913-18-1/Dynorphins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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