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Influence of acute and chronic myocardial loading conditions, function, structural changes and extracardiac factors on NT-proBNP in asymptomatic patients with preserved ejection fraction.
MedLine Citation:
PMID:  20811898     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: We compared the effect of different loading conditions, parameters of structural heart disease and extracardiac confounders on NT-proBNP to validate the application of NT-proBNP for a characterisation of loading conditions and clinical course of patients with chronic heart diseases.
METHODS: NT-proBNP was measured in 15 controls and 34 patients with preserved ejection fraction and chronic pressure (by aortic stenosis) or volume overload (by aortic or mitral regurgitation) before and after physical as well as dobutamine stress. Myocardial fibrosis was evaluated by contrast-enhanced cardiovascular magnetic resonance.
RESULTS: In patients with elevated NT-proBNP due to chronic pressure or volume overloaded ventricles, physical and dobutamine stress were associated with only marginal nonsignificant additional NT-proBNP responses. Univariate analyses showed that myocardial fibrosis has the greatest effect on NT-proBNP (P < 0.01). Forward regression analyses revealed left ventricular filling, systolic function, the presence of valvular heart disease, serum creatinine and responses to dobutamine stress as independent determinants of NT-proBNP (P < 0.05 each).
CONCLUSION: NT-proBNP cannot be used simply to characterise intensity of ventricular load. Character and duration of loading conditions, cardiac structure and function, as well as confounders should be considered when NT-proBNP is used for clinical follow-up assessment.
Olaf Schulz; Andre Rudolph; Sarah Scheiner; Helena Mut; Jeanette Schulz-Menger; Gunnar Berghoefer; Ricarda Bensch; Jochen Kraemer; Ingolf Schimke
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Publication Detail:
Type:  Journal Article     Date:  2010-09-02
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  100     ISSN:  1861-0692     ISO Abbreviation:  Clin Res Cardiol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  57-65     Citation Subset:  IM    
Interventionelle Kardiologie Spandau, Neuendorfer Str. 70, 13585, Berlin, Germany,
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