Document Detail

Influence of acid-pepsin secretion on gastric emptying of solids in humans: studies with cimetidine.
MedLine Citation:
PMID:  1752458     Owner:  NLM     Status:  MEDLINE    
The commonly accepted model for gastric emptying suggests that the 'antral mill' is responsible for the triturition and subsequent emptying of solid food from the stomach. Little is known about the contribution to solid emptying made by other digestive mechanisms such as acid-pepsin secretion. We have investigated the effect of inhibiting gastic secretion on the rate at which a solid test meal emptied from the stomach. Using a radiolabelled beefburger, we performed paired gammacamera studies on consecutive days in 10 fasted, healthy volunteers to compare gastric emptying of the test meal with and without oral cimetidine (400 mg 1 hour before the test, 800 mg at the start of the meal). Inhibition of acid-pepsin secretion by cimetidine was associated with an appreciable delay in the rate of emptying of the burger from the stomach (T50 cimetidine 187 (16) min (mean (SEM); T50 no cimetidine 146 (15) min; p less than 0.01, paired t test). This delay was related to a change in the slope of the emptying profile and was not associated with a prolonged lag phase. These results may be explained by the relative achlorhydria and reduced pepsin activity induced by cimetidine impairing the breakdown of solid food into particles small enough to leave the stomach.
D D Kerrigan; Y F Mangnall; N W Read; A G Johnson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  32     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-01-24     Completed Date:  1992-01-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1295-7     Citation Subset:  AIM; IM    
Department of Surgery, University of Sheffield, Royal Hallamshire Hospital.
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MeSH Terms
Cimetidine / diagnostic use
Gastric Acid / secretion*
Gastric Emptying / physiology*
Pepsin A / secretion*
Time Factors
Reg. No./Substance:
51481-61-9/Cimetidine; EC A

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