Document Detail

Influence of Uncertainties in the Material Properties of Brain Tissue on the Probabilistic Volume of Tissue Activated.
MedLine Citation:
PMID:  23269746     Owner:  NLM     Status:  Publisher    
The aim of this study was to examine the influence of uncertainty of the material properties of brain tissue on the probabilistic voltage response and the probabilistic volume of tissue activated in a volume conductor model of deep brain stimulation. To quantify the uncertainties of the desired quantities without changing the deterministic model, a nonintrusive projection method was used by approximating these quantities by a polynomial expansion on a multi-dimensional basis known as Polynomial Chaos. The coefficients of this expansion were computed with a multi-dimensional quadrature on sparse Smolyak grids. The deterministic model combines a finite element model based on a digital brain atlas and a multi-compartmental model of mammalian nerve fibres. The material properties of brain tissue were modelled as uniform random parameters using data from several experimental studies. Different magnitudes of uncertainty in the material properties were computed to allow predictions on the resulting uncertainties in the desired quantities. The results showed a major contribution of the uncertainties in the electrical conductivity values of brain tissue on the voltage response as well as on the predicted volume of tissue activated, while the influence of the uncertainties in the relative permittivity was negligible.
C Schmidt; P Grant; M Lowery; U van Rienen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-21
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  -     ISSN:  1558-2531     ISO Abbreviation:  IEEE Trans Biomed Eng     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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