| Influence of UVB therapy on dermoscopic features of acquired melanocytic nevi. | |
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MedLine Citation:
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PMID: 9344193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Exposure to UV radiation can lead to clinical, histologic, and ultrastructural changes in acquired melanocytic nevi. OBJECTIVE: We investigated whether UVB therapy can induce changes in melanocytic nevi detectable by dermoscopy. METHODS: Eighty acquired melanocytic nevi of 13 patients (10 females, 3 males; mean age, 28 years; range, 13 to 62 years) undergoing UVB therapy were documented under standardized conditions by means of a Dermaphot apparatus before and at the end of suberythemal UVB therapy. The mean duration of therapy was 8 weeks (range, 2 to 17 weeks) and the mean total UVB dose was 1120 mJ/cm2 (range, 247 to 2771 mJ/cm2). During UV irradiation, 40 nevi were left unprotected and 40 nevi were protected from UV exposure in a randomized manner. Color dermoscopic images of nevi before and after UVB therapy were projected side by side and examined blindly by five investigators. Fifteen different features were evaluated in the nevi. RESULTS: Unprotected nevi became more irregular (p < or = 0.01) and darker brown (p < or = 0.03) by the end of the therapy, whereas the protected nevi showed no significant changes. CONCLUSION: Suberythemal UVB therapy can lead to changes in the dermoscopic image of acquired melanocytic nevi, presumably by activating melanocytes. |
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Authors:
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R Hofmann-Wellenhof; P Wolf; J Smolle; A Reimann-Weber; H P Soyer; H Kerl |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 37 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1997-11-13 Completed Date: 1997-11-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 559-63 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of Graz, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Color Female Humans Male Melanocytes / pathology, radiation effects Microscopy Middle Aged Nevus, Pigmented / pathology, radiotherapy* Radiation Protection Radiotherapy Dosage Single-Blind Method Skin / pathology, radiation effects Skin Neoplasms / pathology, radiotherapy* Skin Pigmentation / radiation effects Time Factors Ultraviolet Rays / classification Ultraviolet Therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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