Document Detail

Influence of trace elements on stabilization of aqueous solutions of ascorbic acid.
MedLine Citation:
PMID:  23099563     Owner:  NLM     Status:  MEDLINE    
Together with vitamin C, zinc, selenium, manganese, and magnesium play a vital role in the preservation of organs scheduled for transplantation. In the present study, it is shown that addition of 1 mg/l of these elements influences the stability of 0.3 mM ascorbic acid solutions. The solution's stability was estimated using an accelerated stability test. The concentration of vitamin C was measured using a validated spectrophotometric method, which uses the reduction of 2,6-dichlorophenoloindophenol by ascorbic acid. Elevated temperatures, the factor accelerating substances' decomposition reaction rate, were used in the tests. The research was conducted at two temperatures at intervals of 10 °C: 80 ± 0.1 and 90 ± 0.1 °C. It was stated that the studied substances' decomposition occurred in accordance with the equation for first-order reactions. The function of the logarithmic concentration (log%C) over time was revealed to be rectilinear. This dependence was used to determine the kinetics of decomposition reaction rate parameters. The stabilization of vitamin C solutions was measured as the time in which 10 % of the substance decomposed at 20 and 0 °C. Addition of Se(IV) or Mg(II) ions significantly increase the stability of ascorbic acid solution (∼34 and ∼16 %, respectively), but Zn(II) causes a significant decrease in stability by ∼23 %. Addition of Mn(II) has no significant influence on vitamin C stability.
Barbara Dolińska; Aneta Ostróżka-Cieślik; Artur Caban; Klimas Rimantas; Lucyna Leszczyńska; Florian Ryszka
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-26
Journal Detail:
Title:  Biological trace element research     Volume:  150     ISSN:  1559-0720     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-05-14     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-12     Citation Subset:  IM    
Biochefa Pharmaceutical Research and Production Plant, Sosnowiec, Poland.
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MeSH Terms
Antioxidants / analysis,  chemistry*
Ascorbic Acid / analysis,  chemistry*
Drug Stability
Fumarates / chemistry
Hot Temperature
Magnesium / chemistry*
Manganese / chemistry
Manganese Compounds / chemistry
Organ Preservation Solutions / chemistry
Osmolar Concentration
Preservatives, Pharmaceutical / chemistry
Selenium / chemistry*
Sodium Selenite / chemistry
Sulfates / chemistry
Trace Elements / chemistry*
Zinc / chemistry
Zinc Acetate / chemistry
Reg. No./Substance:
0/Antioxidants; 0/Fumarates; 0/Manganese Compounds; 0/Organ Preservation Solutions; 0/Preservatives, Pharmaceutical; 0/Sulfates; 0/Trace Elements; 10102-18-8/Sodium Selenite; 50-81-7/Ascorbic Acid; 5970-45-6/Zinc Acetate; 7439-95-4/Magnesium; 7439-96-5/Manganese; 7440-66-6/Zinc; 7782-49-2/Selenium; 7785-87-7/manganese sulfate; 88XHZ13131/fumaric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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