| The influence of topical diclofenac sodium on the ocular hypotensive effect of latanoprost in glaucoma patients. | |
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MedLine Citation:
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PMID: 20577116 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the effect of diclofenac sodium 0.1% on reducing intraocular pressure (IOP) by latanoprost 0.005% in glaucoma patients. PATIENTS AND METHODS: Twenty-two patients with bilateral primary open angle glaucoma were enrolled in this study. All patients had been given only latanoprost for at least 4 weeks. Topical diclofenac sodium was additionally applied to one eye (dicloptin group), whereas hydroxypropyl methyl cellulose was administered into the other eye (control group); both 4 times a day for 2 weeks. IOP measurement was performed before and 2 weeks after the administrations, and also 2 weeks after discontinuing additional ophthalmic solutions. RESULTS: No significant difference was observed in the IOPs before additional administration of ophthalmic solution between the dicloptin group and the control group (P=0.47). Additional administration of diclofenac sodium increased mean IOP from 15.73±1.75 to 17.32±2.23 mm Hg (P=0.01). This increase was reversed 2 weeks after discontinuing additional solutions (P=0.80); however, no significant difference in mean IOP was observed in the control group after administration and after discontinuing the additional medication (P=0.94 and 0.84, respectively). CONCLUSIONS: Topical diclofenac sodium may interfere with the IOP lowering effect of latanoprost in glaucoma patients; therefore this interference should be noted in coadministration of these drugs. |
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Authors:
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Rana Sorkhabi; Rakhshande Alipanahi; Amir Eftakhari-Milani; Leila Ghojazadeh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of glaucoma Volume: 20 ISSN: 1536-481X ISO Abbreviation: J. Glaucoma Publication Date: 2011 Apr-May |
Date Detail:
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Created Date: 2011-04-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9300903 Medline TA: J Glaucoma Country: United States |
Other Details:
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Languages: eng Pagination: 240-3 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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