Document Detail


The influence of topical diclofenac sodium on the ocular hypotensive effect of latanoprost in glaucoma patients.
MedLine Citation:
PMID:  20577116     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE: To evaluate the effect of diclofenac sodium 0.1% on reducing intraocular pressure (IOP) by latanoprost 0.005% in glaucoma patients.
PATIENTS AND METHODS: Twenty-two patients with bilateral primary open angle glaucoma were enrolled in this study. All patients had been given only latanoprost for at least 4 weeks. Topical diclofenac sodium was additionally applied to one eye (dicloptin group), whereas hydroxypropyl methyl cellulose was administered into the other eye (control group); both 4 times a day for 2 weeks. IOP measurement was performed before and 2 weeks after the administrations, and also 2 weeks after discontinuing additional ophthalmic solutions.
RESULTS: No significant difference was observed in the IOPs before additional administration of ophthalmic solution between the dicloptin group and the control group (P=0.47). Additional administration of diclofenac sodium increased mean IOP from 15.73±1.75 to 17.32±2.23 mm Hg (P=0.01). This increase was reversed 2 weeks after discontinuing additional solutions (P=0.80); however, no significant difference in mean IOP was observed in the control group after administration and after discontinuing the additional medication (P=0.94 and 0.84, respectively).
CONCLUSIONS: Topical diclofenac sodium may interfere with the IOP lowering effect of latanoprost in glaucoma patients; therefore this interference should be noted in coadministration of these drugs.
Authors:
Rana Sorkhabi; Rakhshande Alipanahi; Amir Eftakhari-Milani; Leila Ghojazadeh
Related Documents :
9787366 - Trabeculectomy function after cataract extraction.
15751236 - The effect of adjunctive mitomycin c in ahmed glaucoma valve implantation.
8551446 - Intraocular pressure seven years after extracapsular cataract extraction and sulcus imp...
7493236 - The morphology of conjunctiva after long-term topical anti-glaucoma treatment. a quanti...
20932706 - Fixed versus rotating platform total knee arthroplasty: a prospective, randomized, sing...
17656606 - Cumulative dose of hypertension predicts outcome in intracranial hemorrhage better than...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of glaucoma     Volume:  20     ISSN:  1536-481X     ISO Abbreviation:  J. Glaucoma     Publication Date:    2011 Apr-May
Date Detail:
Created Date:  2011-04-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300903     Medline TA:  J Glaucoma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  240-3     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Psychometric evaluation of the glaucoma symptom identifier.
Next Document:  Diagnostic Power of Optic Disc Morphology, Peripapillary Retinal Nerve Fiber Layer Thickness, and Ma...